Phenotypic landscape of schizophrenia-associated genes defines candidates and their shared functions by Thyme et al.
From GWAS to function: a phenotypic atlas of 132 zebrafish mutants sheds light on the role of human schizophrenia-associated genes.
Selected by Daniel Grimes. Read the preLight here
Functional testing of a human PBX3 variant in zebrafish reveals a potential modifier role in congenital heart defects by Farr et al.
Using zebrafish to model the effects of candidate disease gene variants in complex human genetic disorders.
Selected by Hannah Brunsdon. Read the preLight here
Human macrophages survive and adopt activated genotypes in living zebrafish by Paul et al.
Establishment of a simplified physiological model system to investigate human immunity-metastasis crosstalk.
Selected by Giuliana Clemente. Read the preLight here
OptoGranules reveal the evolution of stress granules to ALS-FTD pathology by Zhang et al.
Optogenetic tool to identify and study how chronic stress causes the formation of pathogenic inclusions in neurodegenerative diseases.
Selected by Srivats Venkataramanan. Read the preLight here
TORC1 modulation in adipose tissue is required for organismal adaptation to hypoxia in Drosophila by Lee et al.
Hypoxia is deadly to some organisms but well tolerated by others. New preprint sheds light on how Drosophila larvae are able to survive in low oxygen.
Selected by Sarah Bowling. Read the preLight here
Super-Mendelian inheritance mediated by CRISPR/Cas9 in the female mouse germline by Grunwald et al.
A CRISPR-mediated Selfish Gene? Grunwald and colleagues design a “CopyCat” element that drives its own inheritance in the female mouse germline.
Selected by Rebekah Tillotson. Read the preLight here
An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics by Angelidis et al.
Ageing at single cell resolution: a combined single cell transcriptomic and bulk proteomic map of the mouse lung reveals epigenetic dysregulation and cell type-specific effects of ageing.
Repurposing the quinoline antibiotic nitroxoline to treat infections caused by the brain-eating amoeba Balamuthia mandrillaris by Laurie et al.
Keep your wits about you: Bringing old drugs to the fight against brain-eating amoeba.
Selected by Zhang-He Goh. Read the preLight here
