The landscape of antigen-specific T cells in human cancers by Li et al.
Identifying the specific targets of T cells that can destroy cancer cells is a priority in the field of immunotherapy. Here, the authors use a clustering approach in pan-cancer RNAseq datasets to discover new recurrent targets.
Molecularly distinct models of zebrafish Myc-induced B cell leukemia by Borga et al.
ALL together: development and comparison of distinct zebrafish models of B cell Acute Lymphoblastic Leukemia.
Psychiatric risk gene NT5C2 regulates protein translation in human neural progenitor cells by Duarte et al.
To in vitro and beyond! Establishing the function of a potential mental illness risk gene, NT5C2, and its role in regulating protein synthesis.
Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma by Palamidessi et al.
Endocytic growth factor signaling induces proliferation and solid-to-liquid transitions in confluent epithelial tissues in 2D and 3D cell culture.
Old fibroblasts secrete inflammatory cytokines that drive variability in reprogramming efficiency and may affect wound healing between old individuals by Mahmoudi et al.
Growing older and wiser: researchers reveal a subset of old fibroblasts that promote reprogramming more efficiently than their counterparts.
Simultaneous multiplexed amplicon sequencing and transcriptome profiling in single cells by Saikia et al.
High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes by Singh et al.
What's all the RAGE: DARTing into uncharted droplet-based scRNA-seq territory.
Systematic identification of human SNPs affecting regulatory element activity by van Arensbergen et al.
Assessing the regulatory potential of human genetic variation: use of Massively Parallel Reporter Assays to identify >30,000 SNPs that modulate reporter expression.