The landscape of antigen-specific T cells in human cancersby Li et al.

Identifying the specific targets of T cells that can destroy cancer cells is a priority in the field of immunotherapy. Here, the authors use a clustering approach in pan-cancer RNAseq datasets to discover new recurrent targets.

Selected by Rob Hynds. Read the preLight here

Molecularly distinct models of zebrafish Myc-induced B cell leukemiaby Borga et al.

ALL together: development and comparison of distinct zebrafish models of B cell Acute Lymphoblastic Leukemia.

Selected by Hannah Brunsdon. Read the preLight here

Psychiatric risk gene NT5C2 regulates protein translation in human neural progenitor cellsby Duarte et al.

To in vitro and beyond! Establishing the function of a potential mental illness risk gene, NT5C2, and its role in regulating protein synthesis.

Selected by Joanna Cross. Read the preLight here

Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinomaby Palamidessi et al.

Endocytic growth factor signaling induces proliferation and solid-to-liquid transitions in confluent epithelial tissues in 2D and 3D cell culture.

Selected by Tim Fessenden. Read the preLight here

Old fibroblasts secrete inflammatory cytokines that drive variability in reprogramming efficiency and may affect wound healing between old individualsby Mahmoudi et al.

Growing older and wiser: researchers reveal a subset of old fibroblasts that promote reprogramming more efficiently than their counterparts.

Selected by Shikha Nayar. Read the preLight here

Simultaneous multiplexed amplicon sequencing and transcriptome profiling in single cellsby Saikia et al.


High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytesby Singh et al.

What's all the RAGE: DARTing into uncharted droplet-based scRNA-seq territory.

Selected by Samantha Seah. Read the preLight here

Systematic identification of human SNPs affecting regulatory element activityby van Arensbergen et al.

Assessing the regulatory potential of human genetic variation: use of Massively Parallel Reporter Assays to identify >30,000 SNPs that modulate reporter expression.

Selected by Jesus Victorino. Read the preLight here