Human pancreatic islet 3D chromatin architecture provides insights into the genetics of type 2 diabetes by Miguel-Escalada et al.
From 2D to 3D: A chromatin interactome map of human pancreatic islets provides a 3D view into type 2 diabetes and pancreatic islet biology.
Selected by Carmen Adriaens. Read the preLight here
STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pigmentation pathway by Swoboda et al.
Switching melanoma behaviour with STAT3: STAT3 represses the MITF pathway to drive metastasis
Selected by Hannah Brunsdon. Read the preLight here
LCM-seq reveals unique transcriptional adaption mechanisms of resistant neurons in spinal muscular atrophy by Nichterwitz et al.
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Axon-seq decodes the motor axon transcriptome and its modulation in response to ALS by Nijssen et al.
Neurodegeneration does not affect every neuron equally, but why? Nichterwitz et al. and Nijssen et al. introduced novel transcriptomic profiling methods to somatic motor neurons to find out what accounts for this difference.
Selected by Yen-Chung Chen. Read the preLight here
Damage-induced reactive oxygen species enable zebrafish tail regeneration by repositioning of Hedgehog expressing cells by Roehl et al.
Rethinking redevelopment: damage-induced ROS lead to deployment of a cascade of developmental signalling pathways that is necessary for regeneration, but not development, of the zebrafish tail.
Selected by Alberto Rosello-Diez. Read the preLight here
Incorporation of doxorubicin in different polymer nanoparticles and their anti-cancer activity by Pieper et al.
A whole new world: Characterising the release profile and biological efficacy of three doxorubicin-loaded nanoparticle formulations.
Selected by Zhang-He Goh. Read the preLight here
Target-specific precision of CRISPR-mediated genome editing by Chakrabarti et al.
The predictability of genome editing outcome varies across target sites and primarily depends on the nucleotide in the -4 position from the PAM site. Careful selection of target site is therefore key to inducing a specific desired modification.
PUMILIO hyperactivity drives premature aging of Norad-deficient mice by Kopp et al.
An (un)expected surprise? NORAD lncRNA regulates tissue homeostasis, genome integrity and mitochrondrial function in vivo.
Selected by Carmen Adriaens. Read the preLight here
Raincloud plots: a multi-platform tool for robust data visualization by Allen et al.
Let it rain! Using raincloud plots to better visualise data.
Selected by Samantha Seah. Read the preLight here
