DMM would like to congratulate founding editor Allan Spradling on receiving the 2008 Gruber Genetics Prize. This award bestows a gold medal and US$500,000 in recognition of an outstanding scientist whose unusual talents have made significant contributions to genetics research. Spradling, director of the Carnegie Institution’s Department of Embryology, used the fruit fly to discover the first described stem cell niche in the fly ovary. He was also a co-developer of the first techniques that provided successful gene insertion into the fly genome. His work has advanced the tractability of the fly as a model organism and has significantly advanced our understanding of stem cells and their niches.