Patients with autosomal dominant polycystic kidney disease (ADPKD) develop fluid-filled renal cysts that can precipitate kidney failure. PKD1 and PKD2, which are compromised in familial ADPKD, encode polycystin proteins that combine to form a cation channel in the sensory cilia of the renal epithelium. Miller and Portman show that polycystin homologues in C. elegans interact with a novel transmembrane protein CWP-5. CWP-5 mutation disrupts the formation of sensory cilia and may prevent toxic polycystin forms from reaching cilia.
IN THIS ISSUE| 07 July 2010
Polycystin toxicity in C. elegans
Online Issn: 1754-8411
Print Issn: 1754-8403
Dis Model Mech (2010) 3 (7-8): 397.
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Polycystin toxicity in C. elegans. Dis Model Mech 7 July 2010; 3 (7-8): 397. doi:
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