This article includes recent preLights posts that discuss preprints in the field of disease biology.
Featured preLight
Triglyceride metabolism controls inflammation and APOE4-associated disease states in microglia by Roxan A. Stephenson et al.
Graphical summary of the Stephenson et al. preprint created by Gustavo Stelzer showing that lipid metabolism participates in phenotypical changes induced by LPS or APOE4 on human iPSC-derived microglia. Created with BioRender.com.
preLighter(s)
Gustavo Stelzer, PhD student at Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Why it was selected
“The authors show in an elegant, well-structured and easy-to-understand way that triglyceride metabolism is directly related to microglial activation...Through this work, the researchers add more data that strengthen the association between lipid metabolism and inflammation. The authors also open up new possibilities with regard to Alzheimer's disease treatment through controlling triglyceride metabolism. Even with its limitations, metabolic pathways modulation is a promising intervention for a myriad of diseases and should be studied in the next years.”
Other relevant preLight posts
Impaired 26S proteasome causes learning and memory deficiency and induces neuroinflammation mediated by NF-κB in mice by Christa C. Huber et al.
This preprint shows for the first time the importance of the Psmc1 gene as a regulator of proteasome activity, learning, memory and neuroinflammation (common Alzheimer's disease symptoms).
Selected by Gustavo Stelzer and Marcus Oliveira. Read the preLight.
The bat Influenza A virus subtype H18N11 induces nanoscale MHCII clustering upon host cell attachment by Maria Kaukab Osman et al.
Sialic acid, who? Bat influenza A virus H18N11 interacts with host cells by inducing nanoscale MHCII clustering.
Selected by Mitchell Sarmie and Mohammed A. Jalloh. Read the preLight.
High-fat and high-sucrose diet-induced hypothalamic inflammation shows sex specific features in mice by Gabriela C. De Paula et al.
What are the differences in hypothalamic inflammation between male and female models of obesity? And in which model is it reversible?
Selected by Jimeng Li. Read the preLight.
Sexually dimorphic role of diet and stress on behavior, energy metabolism, and the ventromedial hypothalamus by Sanutha Shetty et al.
Shetty and colleagues investigate the combined effects of a high fat diet and acute stress on behaviour, energy metabolism, and peripheral and central inflammation.
Selected by Jimeng Li. Read the preLight.
Effects of early life adversity and adolescent basolateral amygdala activity on corticolimbic connectivity and anxiety behaviors by Caitlyn R. Cody et al.
What goes around comes around - How the environment shapes our brain.
Selected by Nicole Bertola. Read the preLight.
