This article includes recent preLights posts that discuss preprints in the field of disease biology.

Glycan-specific IgM is critical for human immunity to Staphylococcus aureus by Astrid Hendriks et al.

Read the preLight.

WTA-specific IgM supports immune-mediated clearance of S. aureus killing in vitro and in vivo mouse infection experiments. Figure 2 from Hendriks et al., 2023 (BioRxiv) published under a CC-BY-NC-ND 4.0 International license.


Lucy Bowden, Graduate Student at the Brigham Young University, Utah, USA

Why it was selected

“This preprint caught my attention because of its focus on IgM antibodies, which are often overlooked in favor of the more differentiated IgG antibodies. With the rising challenge of antibiotic-resistant bacteria, it is crucial to explore alternative treatment methods and vaccination strategies.”

Effects of Aerobic Exercise in Hepatic Lipid Droplet-Mitochondria interaction in Non-alcoholic Fatty Liver Disease by Juan Carlos Bórquez et al.

Non-alcoholic fatty liver disease induced by a high-fat diet increases the association of mitochondria with lipid droplets, which can be reversed by a treadmill running routine.

Selected by Hellen Costa and Marcus Oliveira. Read the preLight.

Metabolomic profiling reveals effects of marein on energy metabolism in HepG2 cells by Baoping Jiang et al.

Marein, the main component of Coreopsis tinctoria, prevents high glucose toxicity by altering the hepatic cell metabolomic profile.

Selected by Hellen Costa and Marcus Oliveira. Read the preLight.

NAD+ metabolism is a key modulator of bacterial respiratory epithelial infections by Björn Klabunde et al.

Altered NAD+ metabolism in respiratory epithelial cells by Streptococcus pneumoniae sheds light on new infection treatments.

Selected by Matheus Atella de Oliveira and Marcus Oliveira. Read the preLight.

NAD(H) homeostasis is essential for host protection mediated by glycolytic myeloid cells in tuberculosis by Hayden T. Pacl et al.

Mycobacterium tuberculosis hijacks host myeloid cells metabolism by disrupting NAD+ homeostasis, impacting glycolysis, immune response and boosting infection.

Selected by Matheus Atella de Oliveira and Marcus Oliveira. Read the preLight.

H2O2 sulfenylates CHE linking local infection to establishment of systemic acquired resistance by Lijun Cao et al.

30-years of searching for the link between local infection and systemic acquired resistance: It's been ROS all along!

Selected by Marc Somssich. Read the preLight.

PYCR1 Levels Track with Premature and Chronological Skin Aging by Kortessa Sotiropoulou et al.

Eternal youth: Unravelling PYCR1 levels in aging dermal tissues.

Selected by Preethi Krishnaraj. Read the preLight.

VEGFA mRNA-LNP promotes biliary epithelial cell-to-hepatocyte conversion in acute and chronic liver diseases and reverses steatosis and fibrosis by Fatima Rizvi et al.

Steer clear of steatosis – VEGFA lipid nanoparticles (LNPs) drive BEC-hepatocyte conversion, an alternative pathway for liver regeneration.

Selected by Organogenesis and Cancer Program. Read the preLight.

Small extracellular vesicles promote stiffness-mediated metastasis by Alexandra Sneider et al.

Small but mighty: Sneider and colleagues demonstrate the impact of tissue stiffness on extracellular vesicle-mediated metastasis in breast cancer.

Selected by Jade Chan and yohalie kalukula. Read the preLight.

An oncogenic isoform of septin 9 promotes the formation of juxtanuclear invadopodia by reducing nuclear deformability by Joshua Okletey et al.

A bodyguard to get away: Sept9_i1 influences nuclear rigidity to escape the tissue by invadopodia.

Selected by Megane Rayer. Read the preLight.