Akt/Foxo pathway activation switches apoptosis to senescence in short telomere zebrafish by El-Maï et al.
Pushed into senescence: El-Maï and colleagues elucidate an age-related apoptosis to senescence switch in telomerase deficient zebrafish.
Selected by Lorenzo Lafranchi. Read the preLight here
Patient-derived ovarian cancer organoids mimic clinical response and exhibit heterogeneous inter- and intrapatient drug responses de Witte et al.
Patient-derived organoids meet epithelial ovarian cancer: using organoids to enable personalised therapy.
Selected by Zhang-He Goh. Read the preLight here
Selective K-ATP channel-dependent loss of pacemaking in vulnerable nigrostriatal dopamine neurons by α-synuclein aggregates by Thakur et al.
Why do alpha-synuclein aggregates affect specific neuron populations in Parkinson's disease? alpha-synuclein fibrils stop pacemaking in PD-vulnerable midbrain dopamine neurons but not resistant neurons.
Selected by Jessica Xie. Read the preLight here
Behavioral signatures of a developing neural code by Avitan et al.
Young fish go hunting! Avitan et al. investigate the neural correlates of developing behavioral signatures.
Selected by Amrutha Swaminathan. Read the preLight here
Nix induced mitochondrial fission, mitophagy, and myocyte insulin resistance are abrogated by PKA phosphorylation by da Silva Rosa et al.
Nix's function beyond mitophagy: role of a lipotoxicity-induced Nix in myocyte insulin resistance.
Selected by Sandra Franco Iborra. Read the preLight here
Rab11A regulates the constitutive secretory pathway during Toxoplasma gondii invasion of host cells and parasite replication by Kannan et al.
Rab11A: a central player in the T. gondii constitutive secretory pathway, and in vital steps of the parasites’ journey into the target host cell.
Selected by Mariana De Niz. Read the preLight here
Origin and microenvironment contribute to the sexually dimorphic phenotype and function of peritoneal macrophages by Bain et al.
Tissue Residency and Sexually Dimorphic Function in Peritoneal Macrophages.
Selected by Connor Rosen. Read the preLight here
Combining antibiotics with antivirulence compounds is effective and can reverse selection for antibiotic resistance in Pseudomonas aeruginosa by Rezzoagli et al.
No use resisting: reversing antibiotic resistance using combinations of antibiotics and anti-virulence compounds.
Selected by Zhang-He Goh. Read the preLight here
Programmable CRISPR interference for gene silencing using Cas13a in mosquitoes by Kulkarni et al.
CRISPR-Cas13 is the new RNAi: A new and improved version of gene editing and expression manipulation.
Selected by Yasmin Lau. Read the preLight here
