CXCR3-expressing metastasis-initiating cells induce and exploit a fibroblast niche in the lungs to fuel metastatic colonization by Pein et al.
A new place to call home: disseminated cancer cells fleece lung fibroblasts to fuel a metastatic niche.
Selected by Julija Hmeljak. Read the guest preLight here
Myc instructs and maintains pancreatic adenocarcinoma phenotype by Sodir et al.
Flipping on and off Myc can turn on or off pancreatic cancer.
Selected by William Hill. Read the preLight here
Thyroid hormone regulates distinct paths to maturation in pigment cell lineages by Saunders et al.
Thyroid hormone regulation of zebrafish pigment cells – not a black and white (or yellow) issue.
Selected by Hannah Brunsdon. Read the preLight here
Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases by Yambire et al.
Putting the brakes on mitochondrial biogenesis: how lysosomal dysfunction can influence mitochondrial dynamics.
Selected by Sandra Franco Iborra. Read the preLight here
Hepatocyte-specific deletion of Pparα promotes NASH in the context of obesity by Regnier et al.
Fatty liver and PPARα: Is it all in the liver? Regnier et al. study the role of hepatic and extrahepatic PPARα in a mouse model of diet-induced obesity.
Selected by Pablo Ranea. Read the preLight here
MicroRNA-mediated control of developmental lymphangiogenesis by Jung et al.
microRNA, macro responsibilities: miRNA-204-mediated regulation of Nfatc1 is important for development of proper lymphatic vessels.
Selected by Rudra Nayan Das. Read the preLight here
Human Handedness: Genetics, Microtubules, Neuropsychiatric Diseases and Brain Language Areas by Wiberg et al.
Have you ever thought about the factors that make you a right- or a left-hander? This preprint looks into the genetics of human handedness, the first genome-wide study of its kind.
Selected by Jose Guerrero. Read the preLight here
A DNA-based voltmeter for organelles by Saminathan et al.
Electrically excitable organelles? Measuring subcellular membrane potentials with a DNA-based voltmeter.
Selected byRobert Mahen. Read the preLighthere
Self-reporting transposons enable simultaneous readout of gene expression and transcription factor binding in single cells by Moudgil et al.
Making a mark on gene regulatory networks: A method using transposon insertions directed by a transcription factor allows simultaneous mapping of transcription factor binding sites and gene expression in single cells.
Selected by James Briscoe. Read the guest preLight here
Conditional Guide RNAs: Programmable Conditional Regulation of CRISPR/Cas Function in Bacteria via Dynamic RNA Nanotechnology by Hanewich-Hollatz et al.
gRNAs for Cas9 are engineered such that they only get activated upon specific RNA triggers. This could one day open the door to linking signaling pathways with Cas9 function.
Selected by Pavithran Ravindran. Read the preLight here
Prospective, brain-wide labeling of neuronal subclasses with enhancer-driven AAVs by Graybuck et al.
Towards precise targeting of single cell types: enhancer-driven gene expression and engineered viral vectors to improve specificity.
Selected by Jesus Victorino. Read the preLight here
