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Disease Models & Mechanisms (DMM) is an Open Access biomedical research journal advancing novel insight into the mechanism, diagnosis and therapy of human disease.

DMM is committed to publishing rigorously peer-reviewed research in disease biology that has significant translational impact at the interface of basic and clinical science. Our content is freely available to our communities of basic and clinical researchers, health professionals, patients and their advocates and families. DMM is interdisciplinary in scope, and covers a diverse range of diseases. We also publish cutting-edge techniques and resources that advance the disease biology field.

DMM is led by an international team of expert research-active Editors, including Editor-in-Chief Liz Patton and Deputy Editor-in-Chief Elaine Mardis, and supported by an outstanding Editorial Advisory Board.

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DMM marks 100 years of insulin

It has been 100 years since the discovery of insulin. This then revolutionary treatment now saves the lives of millions of people living with diabetes, but much remains to be understood of its mechanisms and roles in homeostasis and disease.

DMM marked the centenary of the discovery of insulin with specially commissioned articles. More articles can be found in our Metabolic Disorders collection.

EDITORIAL: What lies beyond 100 years of insulin.

A MODEL FOR LIFE: Celebrating 100 years of insulin with Dr Elizabeth Seaquist.

PERSPECTIVE: Advances in diet-induced rodent models of metabolically acquired peripheral neuropathy by Stéphanie A. Eid and Eva L. Feldman

PERSPECTIVE: Insulin at 100 years – is rebalancing its action key to fighting obesity-related disease? by Gemma V. Brierley and Robert K. Semple

DMM Special Issue

The RAS Pathway: Diseases, Therapeutics and Beyond

Guest Editors: Donita Brady and Arvin Dar

Recent work has highlighted the roles of RAS dysregulation in cancer, aging and developmental disorders. Our new special issue, The RAS Pathway: Diseases, Therapeutics and Beyond, is now open.

Find new research articles, as well as an inspiring interview with Shiva Malek.




Recent articles from DMM


DMM Editors Monkol Lek and Elaine Mardis give their perspective on approaches to improve ethnic representation in the human genome reference sequence, enabling its widespread use in genomic studies and precision medicine to benefit all peoples.

A Model for Life interview

DMM interviews world-leading developmental, evolutionary and stem cell biologist Peter Currie.


Stroke imaging has undergone seismic shifts in the past decade. Saha and colleagues describe current approaches and advances in the imaging of stroke.

Robert Huber discusses work in different model systems and humans examining the impact of altered protein secretion in the neuronal ceroid lipofuscinoses group of diseases (known as Batten disease).

Editor’s Choice

Eckhard Wolf and colleagues present a genetically tailored pig model that develops the hallmarks of Duchenne muscular dystrophy in an accelerated mode, providing a new resource for testing targeted therapies.

Featured article

Okada et al. describe CRISPR/Cas9 genome-engineered mouse models of musculocontractural Ehlers-Danlos syndrome that may facilitate further understanding of the disorder. 

Journals from The Company of Biologists

Development current cover
Journal of Cell Science current cover
Journal of Experimental Biology current cover
Disease Models and Mechanisms current cover
Biology Open current cover
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