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Disease Models & Mechanisms (DMM) is an Open Access biomedical research journal advancing novel insight into the mechanism, diagnosis and therapy of human disease.

DMM is committed to publishing rigorously peer-reviewed research in disease biology that has significant translational impact at the interface of basic and clinical science. Our content is freely available to our communities of basic and clinical researchers, health professionals, patients and their advocates and families. DMM is interdisciplinary in scope, and covers a diverse range of diseases. We also publish cutting-edge techniques and resources that advance the disease biology field.

DMM is led by an international team of expert research-active Editors, including Editor-in-Chief Liz Patton and Deputy Editor-in-Chief Elaine Mardis, and supported by an outstanding Editorial Advisory Board.

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DMM included in Read & Publish agreements

From 2022, DMM is included in many of the Read & Publish agreements offered by The Company of Biologists. This enables discounted or fee-free publication of an uncapped number of Research articles in DMM for corresponding authors at participating institutions (including, among others, the Max Planck Digital Library and University of California).

Read more about the ways in which DMM is working to increase accessibility for both authors and readers in an Editorial from Editor-in-Chief Liz Patton.

Special article

Lack of reproducibility in animal studies continues to be a challenge; improving this is a National Institutes of Health priority. Key strategies to enhance translatability are offered and discussed by The Jackson Laboratory investigators in a new perspective.

Free online access to all articles.




Defining the unknowns for cell therapies in Parkinson's disease

Cell therapies for Parkinson's disease have entered into first-in-human clinical trials. Emma Lane and Mariah Lelos discuss pertinent outstanding questions that require consideration before widespread adoption of this therapeutic intervention.

Molecular inhibition of RAS signalling to target ageing and age-related health

Mihails Laskovs, Linda Partridge and Cathy Slack critically discuss the links between RAS signalling and ageing, and how RAS inhibitors could extend lifespan and enhance health.

The Finnish genetic heritage in 2022 – from diagnosis to translational research

Reetta Hinttala and colleagues outline the unique enrichment of variants causing Finnish disease heritage disorders, and the discovery of novel genotype–phenotype associations underlying monogenic and common complex diseases.

Editor's choice

Targeting firing rate neuronal homeostasis can prevent seizures

Epilepsy remains challenging to treat. Baines and colleagues show that manipulating endogenous mechanisms that maintain stability of neuronal activity represents a possible route to better manage this disorder.

Sharing resources to advance translational research

DMM is pleased to announce the launch of our new ‘Outstanding Resource Paper Prize’, which will allow us to promote and encourage excellence in Resource articles. This will support our goal to encourage collaboration, improve reproducibility and promote robust translation from bench to bedside.

Journals from The Company of Biologists

Development current cover
Journal of Cell Science current cover
Journal of Experimental Biology current cover
Disease Models and Mechanisms current cover
Biology Open current cover
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