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Disease Models & Mechanisms (DMM) is an Open Access biomedical research journal focusing on the use of model systems to better understand, diagnose and treat human disease.

The primary aim of DMM is to promote human health by inspiring collaboration between basic and clinical researchers in translational science. The journal is committed to presenting rigorously peer-reviewed research that has significant translational impact. The interdisciplinary nature of DMM means that a diverse range of diseases, approaches and models fall within its broad scope. DMM is guided by an international team of expert research-active Editors, led by Editor-in-Chief Elizabeth Patton and Deputy Editor-in-Chief Elaine Mardis, and supported by an outstanding Editorial Advisory Board.

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Virtual Journal Meeting: Developmental Disorders: From Mechanism to Treatment

Applications are now welcome for the joint Development and Disease Models & Mechanisms virtual meeting taking place in September. Hear from the organisers of #DEVDMM21 as Monica Justice, Lee Niswander, Phil Beales and James Briscoe explain why this Meeting will be unique.

Current issue highlights

Imbalances in the gut microbiome are implicated in many localised and systemic disease states. Two new articles, a Perspective from Mariana Byndloss and colleagues and a Review from Mark Huycke et al., discuss how changes to the composition of the gut microbiome affect the colonic epithelium and contribute to colorectal cancer pathogenesis. These articles are part of our Human Host-Microbiome Interactions in Health and Disease subject collection, which gives a snapshot of the complexity of the microbiome, its role in maintaining human health and the consequences of its dysregulation.

News from DMM

Editor-in-Chief Editorial

In her first Editorial as Editor-in-Chief, Liz Patton sets out her vision and priorities for DMM, focusing on four thematic challenges: mechanisms of disease, innovative technologies, disease progression through time and therapy.

DMM Editor team

Meet the latest recruits to the DMM Editor team: Sally Dunwoodie, Monkol Lek and Rickie Patani. We also welcome Esther Verheyen and Iwei Yeh to the Editorial Advisory Board.

New website

The DMM website has changed following our move to a new publishing platform. If you have any questions, please visit our migration page, which includes more information and FAQs.

Editor’s Choice

Joshua Waxman’s group use a zebrafish model of the rare inherited condition primary ciliary dyskinesia to link myeloid cell defects to Cdcc103 function. They show that Ccdc103 regulates myeloid migration and proliferation independent of motile cilia. Learn more in our interview with first author Lauren Falkenberg.

Featured article

Sergio Casas-Tintó and colleagues used a Drosophila crush injury model to investigate the cellular, genetic and immune mechanisms of central nervous system injury and regeneration. Learn more about this paper in our First Person interview with Maria Losada-Perez.

Journals from The Company of Biologists

Development current cover
Journal of Cell Science current cover
Journal of Experimental Biology current cover
Disease Models and Mechanisms current cover
Biology Open current cover
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