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Disease Models & Mechanisms (DMM) is an Open Access biomedical research journal advancing novel insight into the mechanism, diagnosis and therapy of human disease.

DMM is committed to publishing rigorously peer-reviewed research in disease biology that has significant translational impact at the interface of basic and clinical science. Our content is freely available to our communities of basic and clinical researchers, health professionals, patients and their advocates and families. DMM is interdisciplinary in scope, and covers a diverse range of diseases. We also publish cutting-edge techniques and resources that advance the disease biology field.

DMM is led by an international team of expert research-active Editors, including Editor-in-Chief Liz Patton and Deputy Editor-in-Chief Elaine Mardis, and supported by an outstanding Editorial Advisory Board.

About DMM

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Read & Publish agreements

You might be able to publish in DMM without paying an Article Processing Charge. DMM is included in many of the Read & Publish agreements offered by The Company of Biologists.

Corresponding authors at institutions with the five-journal package can publish an uncapped number of Open Access Research articles and Resources & Methods articles in DMM (and the other Company journals) without paying the Article Processing Charge.

Find out whether your institution has a Read & Publish agreement that includes DMM and whether you can publish in DMM for free.

Hear from DMM authors who have already benefitted from publishing in DMM under a Read & Publish agreement.

The Forest of Biologists The Forest of Biologists leaves icon

As part of a biodiversity initiative from The Company of Biologists, DMM now plants a native tree in a UK forest for each published Research and Review article. We are also funding the restoration and preservation of ancient woodland and dedicating these trees to our peer reviewers. All of these trees are represented together in a virtual forest.

Read the Editorial to find out more about the launch of this initiative.

Perspective

Modelling the micro- and macro- environment of pancreatic cancer: from patients to pre-clinical models and back

Eloise Lloyd, Joaquín Henríquez and Giulia Biffi discuss how pre-clinical mouse models could be improved to exemplify key features of the complex micro- and macro- environments of pancreatic cancer. This could drive clinically relevant patient stratification, tailored treatments and improved survival.

At A Glance

Degron tagging for rapid protein degradation in mice

Andrew Wood and colleagues illustrate recent applications of degron tagging in mouse models, including understanding disease mechanisms, modelling therapeutic interventions and constructing synthetic gene networks.

Review

Molecular functions of ANKLE2 and its implications in human disease

Priya Shah and colleagues review the molecular roles of scaffolding protein ANKLE2 in cell division and brain development, and discuss recent studies on human diseases caused by its dysfunction.

Editor's choice

HIF-1α-dependent upregulation of angiogenic factors by mechanical stimulation in retinal pigment epithelial cells by Atsushige Ashimori, Fumiaki Higashijima, Tadahiko Ogata, Ayano Sakuma, Waka Hamada, Junki Sunada, Ren Aoki, Masanori Mikuni, Ken'ichiro Hayashi, Makiko Wakuta, Takuya Yoshimoto, Akira Minamoto, Ji-Ae Ko and Kazuhiro Kimura

In this month’s Editor’s choice Research article, Kazuhiro Kimura and colleagues mechanically stimulated retinal pigment epithelial cells to model drusen-type age-related macular degeneration (AMD). They found that angiogenic factors were upregulated via an SRC–p38–HIF-1α axis, shedding light on the pathological mechanisms of this condition.

We summarize the findings of this study, which encourage further investigation of HIF-1α inhibitors as a potential treatment for AMD.

Journals from The Company of Biologists

Development current cover
Journal of Cell Science current cover
Journal of Experimental Biology current cover
Disease Models and Mechanisms current cover
Biology Open current cover
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