Disease Models & Mechanisms (DMM) is an Open Access biomedical research journal focusing on the use of model systems to better understand, diagnose and treat human disease.
The primary aim of DMM is to promote human health by inspiring collaboration between basic and clinical researchers in translational science. The journal is committed to presenting rigorously peer-reviewed research that has significant translational impact. The interdisciplinary nature of DMM means that a diverse range of diseases, approaches and models fall within its broad scope. DMM is guided by an international team of expert research-active Editors, led by Editor-in-Chief Elizabeth Patton and Deputy Editor-in-Chief Elaine Mardis, and supported by an outstanding Editorial Advisory Board.
New Perspectives from DMM
Hans Clevers and colleagues discuss the powerful potential of lung organoids in our quest to understand and treat COVID-19 infection.
Scott Baraban describes how zebrafish-based screening programmes can reshape drug discovery for the treatment of epilepsy.
Mariana Byndloss and colleagues explore the mechanistic insights and future research directions connecting Western lifestyle-induced changes in colonic epithelial physiology with the outgrowth of tumorigenic bacteria that contribute to colorectal cancer pathogenesis.
DMM Special Issue
The RAS Pathway: Diseases, Therapeutics and Beyond
Guest editors: Donita Brady and Arvin Dar
Recent work has highlighted the roles of RAS dysregulation in cancer, aging and developmental disorders. Our new Special Issue, The RAS Pathway: Diseases, Therapeutics and Beyond, is now open.
Mikael Nilsson et al. show how a BRAF-mutant lineage becomes cancerized by escaping cell competition from non-mutant cells in a mouse model of sporadic thyroid cancer. La Mantia et al. reveal that altered division of trigeminal ganglion progenitors prefigures divergent trigeminal sensory neuron differentiation and oropharyngeal dysfunction in the LgDel mouse model of 22q11.2 deletion syndrome.
Reviews from DMM
Jerome Mertens and colleagues discuss the mechanism of metabolic alterations in neural cell fate during development and adulthood, as well as how it contributes to neurological diseases.
A new Review by Tjakko J. van Ham’s group explores how animal models and the study of leukodystrophy patient material can inform the role of microglia in a diverse range of brain disorders.
Andy Golden and colleagues provide an overview of the use of Caenorhabditis elegans to genetically model rare diseases and enable the discovery of novel therapeutics.
A Resource article from Carmona-Fontaine and colleagues describes the development of and extensive guidelines for the replication of the MEMIC cell culture system, which models the complexity of the tumour microenvironment.
A newly established Drosophila model from Dubrovsky et al. recapitulates key features of human heart pathology linked to mutations in ELAC2, thus providing experimental evidence of the pathogenicity of ELAC2 variants.