Disease Models & Mechanisms (DMM) is an Open Access biomedical research journal advancing novel insight into the mechanism, diagnosis and therapy of human disease.
DMM is committed to publishing rigorously peer-reviewed research in disease biology that has significant translational impact at the interface of basic and clinical science. Our content is freely available to our communities of basic and clinical researchers, health professionals, patients and their advocates and families. DMM is interdisciplinary in scope, and covers a diverse range of diseases. We also publish cutting-edge techniques and resources that advance the disease biology field.
DMM is led by an international team of expert research-active Editors, including Editor-in-Chief Liz Patton and Deputy Editor-in-Chief Elaine Mardis, and supported by an outstanding Editorial Advisory Board.
Subject collections
DMM subject collections are curated lists of articles covering diverse aspects of disease research.
We feature papers on disease areas such as cancer, infectious diseases, neurodegenerative disorders and neuromuscular diseases, among others. Our collections also highlight the translational impact of different model organisms such as zebrafish and Drosophila.
Our ‘Building Advocacy into Research’ interview series is aimed at fostering communication and mutual support between the research community and those impacted by disease.
The Company of Biologists: celebrating 100 years
Our not-for-profit publisher, The Company of Biologists, turns 100 this year. In a start-of-year Editorial, we reflect on our extraordinary story and events over the past 100 years. We also summarise the Company's current support for our communities and prepare for some inspiring activities.
History of our journals
Read about DMM’s history and explore the journey of each of our sister journals: Development, Journal of Cell Science, Journal of Experimental Biology and Biology Open.
Editor's choice
Notch3 deletion regulates HIV-1 gene expression and systemic inflammation to ameliorate chronic kidney disease by Mackenzie Thornton, Nicole Sommer, Mercedes McGonigle, Anil Kumar Ram, Sireesha Yerrathota, Henrietta Ehirim, Aakriti Chaturvedi, Johnny Dinh Phan, Anubhav Chakraborty, V. Praveen Chakravarthi, Sumedha Gunewardena, Mudit Tyagi, Jaya Talreja, Tao Wang, Pravin Singhal, Pamela Tran, Timothy Fields, Patricio Ray, Navneet Dhillon and Madhulika Sharma
In this month’s Editor’s choice Research Article, Madhulika Sharma and colleagues reveal a dual role for Notch3 in HIV progression by promoting inflammation as well as activating HIV gene expression.
We summarize the findings of this study, which highlight NOTCH3 as a promising drug target for HIV-related chronic kidney disease.
New perspectives on disease research
DMM publishes Perspectives – peer-reviewed articles that provide expert analysis of a topic important to the disease research community.
Read our collection of Perspectives from authors presenting new or potentially controversial ideas or hypotheses, to help address future challenges and forge new directions.
Translational lessons from the balanced immune system in bats by Wei Lun Ng and Lin-Fa Wang
Immunometabolism and mitochondria in inflammatory bowel disease: a role for therapeutic intervention? by Claire Adams, Duncan Rutherford, Gareth Jones and Gwo-tzer Ho
The preclinical gap in pancreatic cancer and radiotherapy by Mathias Tesson and Jennifer Morton
