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Disease Models & Mechanisms (DMM) is an Open Access biomedical research journal advancing novel insight into the mechanism, diagnosis and therapy of human disease.

DMM is committed to publishing rigorously peer-reviewed research in disease biology that has significant translational impact at the interface of basic and clinical science. Our content is freely available to our communities of basic and clinical researchers, health professionals, patients and their advocates and families. DMM is interdisciplinary in scope, and covers a diverse range of diseases. We also publish cutting-edge techniques and resources that advance the disease biology field.

DMM is led by an international team of expert research-active Editors, including Editor-in-Chief Liz Patton and Deputy Editor-in-Chief Elaine Mardis, and supported by an outstanding Editorial Advisory Board.

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DMM included in Read & Publish agreements

From 2022, DMM is included in many of the Read & Publish agreements offered by The Company of Biologists. This enables discounted or fee-free publication of an uncapped number of Research articles in DMM for corresponding authors at participating institutions (including, among others, the Max Planck Digital Library and University of California).

Read more about the ways in which DMM is working to increase accessibility for both authors and readers in an Editorial from Editor-in-Chief Liz Patton.

Special Issue: Moving Heart Failure to Heart Success

The call for papers for our upcoming special issue Moving Heart Failure to Heart Success: Mechanisms, Regeneration & Therapy has now closed. Articles will be made available online as soon as they are ready for publication. Read the first published articles


The predictive value of models of neuromuscular disorders to potentiate clinical translation

Maaike van Putten discusses advances in modelling neuromuscular disorders to improve the translatability of preclinical studies. DMM also highlights two articles from this issue of DMM that provide a deeper understanding of X-linked myotubular myopathy.

A Model for Life

Breaking the silos, stopping the spread: an interview with Jyoti Joshi.

Genetic Variance in Disease

New technologies, computational methods and model systems are revealing how human genetic variance contributes to disease mechanisms. Our new subject focus highlights this evolving area of research.


Recent Reviews from DMM

Cerebral malaria – modelling interactions at the blood–brain barrier in vitro

Yvonne Adams and Anja Ramstedt Jensen review available in vitro models for investigating the impact of adhesion of Plasmodium-falciparum-infected red blood cells on the blood–brain barrier –  a process associated with cerebral malaria.


Pyroptosis in host defence against bacterial infection

Pyroptosis is a form of inflammatory cell death. Dominik Brokatzky and Serge Mostowy compare the interplay between pyroptosis and important human pathogens – Mycobacterium tuberculosis, Salmonella typhimurium and Shigella flexneri – in different models of immune response to infection.

Journals from The Company of Biologists

Development current cover
Journal of Cell Science current cover
Journal of Experimental Biology current cover
Disease Models and Mechanisms current cover
Biology Open current cover
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