Disease Models & Mechanisms (DMM) is an Open Access biomedical research journal focusing on the use of model systems to better understand, diagnose and treat human disease.
The primary aim of DMM is to promote human health by inspiring collaboration between basic and clinical researchers in translational science. The journal is committed to presenting rigorously peer-reviewed research that has significant translational impact. The interdisciplinary nature of DMM means that a diverse range of diseases, approaches and models fall within its broad scope. DMM is guided by an international team of expert research-active Editors, led by Editor-in-Chief Elizabeth Patton and Deputy Editor-in-Chief Elaine Mardis, and supported by an outstanding Editorial Advisory Board.
New perspectives from DMM
Hans Clevers and colleagues discuss the powerful potential of lung organoids in our quest to understand and treat COVID-19 infection.
Scott Baraban describes how zebrafish-based screening programmes can reshape drug discovery for the treatment of epilepsy.
Mariana Byndloss and colleagues explore the mechanistic insights and future research directions connecting Western lifestyle-induced changes in colonic epithelial physiology with the outgrowth of tumorigenic bacteria that contribute to colorectal cancer pathogenesis.
DMM Special Issue
Guest Editors: Donita Brady and Arvin Dar
Recent work has highlighted the roles of RAS dysregulation in cancer, aging and developmental disorders. Our new special issue, The RAS Pathway: Diseases, Therapeutics and Beyond, is now open.
Mikael Nilsson et al. show how a BRAF-mutant lineage becomes cancerized by escaping cell competition from non-mutant cells in a mouse model of sporadic thyroid cancer. La Mantia et al. reveal that altered division of trigeminal ganglion progenitors prefigures divergent trigeminal sensory neuron differentiation and oropharyngeal dysfunction in the LgDel mouse model of 22q11.2 deletion syndrome.
Reviews from DMM
Chromosome rearrangements can be potent cancer drivers and effective therapeutic targets. Alonso and Dow review how genome-editing technologies can be exploited to engineer and study complex structural variants, and identify new treatment options.
In their At a Glance article and poster, Martinez Lyons and Boulter explore the mechanisms of Notch signaling, and discuss how the field has concluded that Notch signaling is a central determinant in bile duct formation and growth.
A study from Obata and colleagues took advantage of Drosophila genetics to demonstrate how mild inflammation in early life can be a risk factor for life-long health through alteration of the gut microbiota.
A zebrafish model of infection was developed by Kremer et al. to evaluate the in vivo cooperative activity of specific phages and antibiotics for the treatment of Mycobacterium abscessus infection.