Disease Models & Mechanisms | The Company of Biologists

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Disease Models & Mechanisms (DMM) is an Open Access biomedical research journal advancing novel insight into the mechanism, diagnosis and therapy of human disease.

DMM is committed to publishing rigorously peer-reviewed research in disease biology that has significant translational impact at the interface of basic and clinical science. Our content is freely available to our communities of basic and clinical researchers, health professionals, patients and their advocates and families. DMM is interdisciplinary in scope, and covers a diverse range of diseases. We also publish cutting-edge techniques and resources that advance the disease biology field.

DMM is led by an international team of expert research-active Editors, including Editor-in-Chief Liz Patton and Deputy Editor-in-Chief Elaine Mardis, and supported by an outstanding Editorial Advisory Board.

DMM included in Read & Publish agreements

From 2022, DMM is included in many of the Read & Publish agreements offered by The Company of Biologists. This enables discounted or fee-free publication of an uncapped number of Research articles in DMM for corresponding authors at participating institutions (including, among others, the Max Planck Digital Library and University of California).

Read more about the ways in which DMM is working to increase accessibility for both authors and readers in an Editorial from Editor-in-Chief Liz Patton.

Editor's choice

Exposure to e-cigarette vapor extract induces vocal fold epithelial injury and triggers intense mucosal remodeling

As vaping increases in popularity, it is becoming more important to understand the impact on our health and ultimately inform health policy decision making. Thibeault and colleagues have revealed the mechanisms of damage caused by vaping in mucosal cells and subsequent epithelial remodelling. The study highlights the human induced pluripotent stem cell derived vocal fold model as a useful tool for future studies.

Editorial

Modelling infectious disease to support human health

A new Editorial from DMM Editor David Tobin considers how knowledge from animal (focusing largely on zebrafish) and other models of infectious disease can impact our understanding of human biology and potential therapies

Special Article

Consensus guidelines on the construct validity of rodent models of restless legs syndrome

The authors of this Special Article summarize the consensus guidelines on the construct validity of rodent models of restless legs syndrome, which have been recently established by a task force of the International Restless Legs Syndrome Study Group.

Genetic Variance in Disease

New technologies, computational methods and model systems are revealing how human genetic variance contributes to disease mechanisms. Our new subject focus highlights this evolving area of research.

Recent Reviews from DMM

Mechanistic insights from animal models of neurofibromatosis type 1 cognitive impairment

Neurofibromin influences neural circuits through RAS, cAMP and dopamine signalling. Andrew Miller and Mary Halloran discuss how exploring the mechanisms underlying neurofibromin-dependent behaviours in animal models might enable future treatment of the various cognitive deficits that are associated with neurofibromatosis type 1.

Cerebral malaria – modelling interactions at the blood–brain barrier in vitro

Yvonne Adams and Anja Ramstedt Jensen review available in vitro models for investigating the impact of adhesion of Plasmodium-falciparum-infected red blood cells on the blood–brain barrier – a process associated with cerebral malaria.

Pyroptosis in host defence against bacterial infection

Pyroptosis is a form of inflammatory cell death. Dominik Brokatzky and Serge Mostowy compare the interplay between pyroptosis and important human pathogens – Mycobacterium tuberculosis, Salmonella typhimurium and Shigella flexneri – in different models of immune response to infection.