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Current Issue
Volume 17,
Issue 5
May 2024

Disease Models & Mechanisms (DMM) is an Open Access biomedical research journal advancing novel insight into the mechanism, diagnosis and therapy of human disease.

DMM is committed to publishing rigorously peer-reviewed research in disease biology that has significant translational impact at the interface of basic and clinical science. Our content is freely available to our communities of basic and clinical researchers, health professionals, patients and their advocates and families. DMM is interdisciplinary in scope, and covers a diverse range of diseases. We also publish cutting-edge techniques and resources that advance the disease biology field.

DMM is led by an international team of expert research-active Editors, including Editor-in-Chief Liz Patton and Deputy Editor-in-Chief Elaine Mardis, and supported by an outstanding Editorial Advisory Board.

About DMM

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Read & Publish agreements

You might be able to publish in DMM without paying an Article Processing Charge. DMM is included in many of the Read & Publish agreements offered by The Company of Biologists.

Corresponding authors at institutions with the five-journal package can publish an uncapped number of Open Access Research articles and Resources & Methods articles in DMM (and the other Company journals) without paying the Article Processing Charge.

Find out whether your institution has a Read & Publish agreement that includes DMM and whether you can publish in DMM for free.

Hear from DMM authors who have already benefitted from publishing in DMM under a Read & Publish agreement.

The Forest of Biologists The Forest of Biologists leaves icon

As part of a biodiversity initiative from The Company of Biologists, DMM now plants a native tree in a UK forest for each published Research and Review article. We are also funding the restoration and preservation of ancient woodland and dedicating these trees to our peer reviewers. All of these trees are represented together in a virtual forest.

Read the Editorial to find out more about the launch of this initiative.

Editorial

DMM Outstanding Paper Prize 2023 winners: Lídia Faria, Ffion R. Hammond and Amy Lewis

DMM is delighted to announce that the winners of the DMM Outstanding Paper Prize 2023 are Lı́dia Faria for their Research Article on the role of an actin signalling pathway in pre-malignant disease development, and Ffion Hammond and Amy Lewis for their Resource Article describing a new zebrafish transgenic line that illuminates immune cell polarisation.

Reviews

Modelling human genetic disorders in Xenopus tropicalis

Helen Willsey and colleagues provide a practical guide for using the frog species Xenopus tropicalis to study pathological genes and variants relevant to human disease, and discuss key considerations in modelling human genetic disorders.

Investigating pulmonary neuroendocrine cells in human respiratory diseases with airway models

Noah Candeli and Talya Dayton provide an overview of pulmonary neuroendocrine cells, with a focus on their role in lung pathologies and how in vitro models can be used to study them.

Editor's choice

Genetic regulation of injury-induced heterotopic ossification in adult zebrafish by Arun-Kumar Kaliya-Perumal, Cenk Celik, Tom Carney, Matthew Harris and Philip Ingham

In this month’s Editor’s choice Research Article, Philip Ingham and colleagues developed a zebrafish injury model of myositis ossificans traumatica (MOT), the inappropriate formation of bone in soft tissues. They identified two pathways upregulated in response to trauma, which suggest that the potassium channel kcnk5b impedes bony overgrowth, whereas the inflammatory gene il11ra worsens MOT.

Jared Talbot highlights how MOT-like phenotypes were clearly induced and modified genetically in this zebrafish model, which may provide insights into MOT in humans and normal regeneration as well.

Journals from The Company of Biologists

Development current cover
Journal of Cell Science current cover
Journal of Experimental Biology current cover
Disease Models and Mechanisms current cover
Biology Open current cover
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