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Disease Models & Mechanisms (DMM) is an Open Access biomedical research journal advancing novel insight into the mechanism, diagnosis and therapy of human disease.

DMM is committed to publishing rigorously peer-reviewed research in disease biology that has significant translational impact at the interface of basic and clinical science. Our content is freely available to our communities of basic and clinical researchers, health professionals, patients and their advocates and families. DMM is interdisciplinary in scope, and covers a diverse range of diseases. We also publish cutting-edge techniques and resources that advance the disease biology field.

DMM is led by an international team of expert research-active Editors, including Editor-in-Chief Liz Patton and Deputy Editor-in-Chief Elaine Mardis, and supported by an outstanding Editorial Advisory Board.

About DMM

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Read & Publish agreements

You might be able to publish in DMM without paying an Article Processing Charge. DMM is included in many of the Read & Publish agreements offered by The Company of Biologists.

Corresponding authors at institutions with the five-journal package can publish an uncapped number of Open Access Research articles and Resources & Methods articles in DMM (and the other Company journals) without paying the Article Processing Charge.

Find out whether your institution has a Read & Publish agreement that includes DMM and whether you can publish in DMM for free.

Hear from DMM authors who have already benefitted from publishing in DMM under a Read & Publish agreement.

The Forest of Biologists The Forest of Biologists leaves icon

As part of a biodiversity initiative from The Company of Biologists, DMM now plants a native tree in a UK forest for each published Research and Review article. We are also funding the restoration and preservation of ancient woodland and dedicating these trees to our peer reviewers. All of these trees are represented together in a virtual forest.

Read the Editorial to find out more about the launch of this initiative.


Valuing peer review at Disease Models & Mechanisms

To start 2024, Liz Patton, Editor-in-Chief of DMM, talks about how peer review serves both authors and readers at DMM. The DMM Editors and editorial team thank all reviewers and co-reviewers of articles submitted to DMM in 2023.


The Mexican Biobank Project promotes genetic discovery, inclusive science and local capacity building

The Mexican Biobank Project represents the first nationwide genomic characterisation of a major country in Latin America. In this Perspective, Mashaal Sohail and Andrés Moreno-Estrada highlight this project as an inspiring example for leading similar initiatives in other parts of the world.

Special Article

Standardization of zebrafish drug testing parameters for muscle diseases

Matthew Alexander and colleagues propose a standardization of criteria for drug screening and evaluation in zebrafish muscle disease models, with the goal of improving experimental rigour, reproducibility and translation.


Validity of Xiphophorus fish as models for human disease

Manfred Schartl and Yuan Lu review how well-established and emerging Xiphophorus fish models and their interspecies hybrids can be used for studying human diseases, and highlight research opportunities enabled by these unique models.

Editor's choice

eNOS plays essential roles in the developing heart and aorta linked to disruption of Notch signalling by Lorraine Eley, Rachel Richardson, Ahlam Alqahtani, Bill Chaudhry and Deborah Henderson

In this month’s Editor’s choice Research Article, Deborah Henderson and colleagues explored cardiovascular abnormalities in eNOS-null mice. They found that eNOS is important for heart and aorta development, most likely via its regulation of Notch signalling.

We summarize these findings, which suggest that eNOS could be a key factor in congenital conditions and that some adult-onset cardiovascular diseases, such as hypertension, may have congenital origins.

Resources & Methods

Transcriptional profiling of Shigella-infected zebrafish

Organoid culture protocols to study oral and esophageal development and carcinogenesis

3D human skin models of psoriasis and atopic dermatitis

Journals from The Company of Biologists

Development current cover
Journal of Cell Science current cover
Journal of Experimental Biology current cover
Disease Models and Mechanisms current cover
Biology Open current cover
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