Disease Models & Mechanisms (DMM) is an Open Access biomedical research journal advancing novel insight into the mechanism, diagnosis and therapy of human disease.
DMM is committed to publishing rigorously peer-reviewed research in disease biology that has significant translational impact at the interface of basic and clinical science. Our content is freely available to our communities of basic and clinical researchers, health professionals, patients and their advocates and families. DMM is interdisciplinary in scope, and covers a diverse range of diseases. We also publish cutting-edge techniques and resources that advance the disease biology field.
DMM is led by an international team of expert research-active Editors, including Editor-in-Chief Liz Patton and Deputy Editor-in-Chief Elaine Mardis, and supported by an outstanding Editorial Advisory Board.
Interdisciplinary approaches to combatting antimicrobial resistance
Register now for our one-day meeting on interdisciplinary approaches to combatting antimicrobial resistance (AMR). To be held on Wednesday 26 March 2025, at the Arena and Convention Centre Liverpool, UK, this event is organised by Katherine R. Duncan (University of Newcastle, UK) and Serge Mostowy (The London School of Hygiene and Tropical Medicine, UK).
The programme has three major themes: (i) drug discovery in the ‘omics era, (ii) cellular mechanisms of AMR, and (iii) detecting and tackling AMR in the environment and clinic. Find out more about the meeting and our great line up of speakers.
Call for Papers: Special Issue – Infectious Disease: Evolution, Mechanism and Global Health
DMM welcomes submissions for our upcoming Special Issue, coordinated by DMM Editors Sumana Sanyal (University of Oxford, UK) and David Tobin (Duke University, USA), alongside Guest Editors Judi Allen (The University of Manchester, UK) and Russell Vance (University of California, Berkeley, USA). Submission deadline: 20 January 2025.
Find out more about the issue and how to submit.
Editor's choice
Axolotl mandible regeneration occurs through mechanical gap closure and a shared regenerative program with the limb by Julia Kramer, Rita Aires, Sean Keeley, Tom Alexander Schröder, Günter Lauer and Tatiana Sandoval-Guzmán
In this month’s Editor’s choice Research Article, Tatiana Sandoval-Guzmán and colleagues analysed the mechanisms underlying the regenerative process of the lower jaw (mandible) in axolotls. They found that regenerating mandibles exhibit similar stages and transcriptomic profiles to those of the regenerating limb.
This study highlights key mechanisms of regeneration in axolotls, and provides insight into limitations of limb regeneration in humans and potential therapeutic targets for regenerative medicine.
