Disease Models & Mechanisms (DMM) is an Open Access biomedical research journal advancing novel insight into the mechanism, diagnosis and therapy of human disease.
DMM is committed to publishing rigorously peer-reviewed research in disease biology that has significant translational impact at the interface of basic and clinical science. Our content is freely available to our communities of basic and clinical researchers, health professionals, patients and their advocates and families. DMM is interdisciplinary in scope, and covers a diverse range of diseases. We also publish cutting-edge techniques and resources that advance the disease biology field.
DMM is led by an international team of expert research-active Editors, including Editor-in-Chief Liz Patton and Deputy Editor-in-Chief Elaine Mardis, and supported by an outstanding Editorial Advisory Board.
Special Issue – Translating Multiscale Research in Rare Disease
Individually, rare diseases might affect only a few people, making them difficult to recognise, diagnose or treat, but collectively, they affect approximately 400 million people globally. In this Special Issue of DMM, we have compiled original Research, Resources & Methods and Review-type articles that focus on the genomics, phenomics, networks, mechanisms and pathways of rare diseases.
Read the Editorial by the Special Issue Editors Monica Justice, Monkol Lek, Karen Liu and Kate Rauen, who reflect on how articles in this issue advance the rare disease research field.
Editor's choice
CCL2 signaling promotes skeletal muscle wasting in non-tumor and breast tumor models by Nadia Alissa, Wei Bin Fang, Marcela Medrano, Nick Bergeron, Yuuka Kozai, Qingting Hu, Chloe Redding, John Thyfault, Jill Hamilton-Reeves, Cory Berkland and Nikki Cheng
In this month’s Editor’s choice Research Article, Nikki Cheng and colleagues combined in vitro and in vivo models to study the role of the chemokine CCL2 in skeletal muscle wasting, experienced by ~25% of patients with breast cancer. They show that tumour-derived CCL2 promotes skeletal muscle wasting through signalling via CCR2-dependent mechanisms.
Nesibe Peker and Johan Vande Voorde highlight the relevance of this study in understanding the mechanisms of cancer cachexia and testing targeted therapies to alleviate tissue wasting in breast cancer.
