Skip to Main Content

Advertisement

Skip Nav Destination

Disease Models & Mechanisms (DMM) is an Open Access biomedical research journal advancing novel insight into the mechanism, diagnosis and therapy of human disease.

DMM is committed to publishing rigorously peer-reviewed research in disease biology that has significant translational impact at the interface of basic and clinical science. Our content is freely available to our communities of basic and clinical researchers, health professionals, patients and their advocates and families. DMM is interdisciplinary in scope, and covers a diverse range of diseases. We also publish cutting-edge techniques and resources that advance the disease biology field.

DMM is led by an international team of expert research-active Editors, including Editor-in-Chief Liz Patton and Deputy Editor-in-Chief Elaine Mardis, and supported by an outstanding Editorial Advisory Board.

About DMM

X icon  Mastodon-icon  Facebook-icon  YouTube-icon  RSS-icon

Read & Publish agreements

You might be able to publish in DMM without paying an Article Processing Charge. DMM is included in many of the Read & Publish agreements offered by The Company of Biologists.

Corresponding authors at institutions with the five-journal package can publish an uncapped number of Open Access Research articles and Resources & Methods articles in DMM (and the other Company journals) without paying the Article Processing Charge.

Find out whether your institution has a Read & Publish agreement that includes DMM and whether you can publish in DMM for free.

Hear from DMM authors who have already benefitted from publishing in DMM under a Read & Publish agreement.

The Forest of Biologists The Forest of Biologists leaves icon

As part of a biodiversity initiative from The Company of Biologists, DMM now plants a native tree in a UK forest for each published Research and Review article. We are also funding the restoration and preservation of ancient woodland and dedicating these trees to our peer reviewers. All of these trees are represented together in a virtual forest.

Read the Editorial to find out more about the launch of this initiative.

Editorial

Sex matters in preclinical research

DMM Editor Monica Justice stresses the need for improved inclusion, analysis and reporting of sex as a biological variable in preclinical animal modelling research.

Perspective

Telomere length is an epigenetic trait – implications for the use of telomerase-deficient organisms to model human disease

Catarina Henriques and Miguel Godinho Ferreira discuss the impact of telomere length on human pathologies, provide a brief overview of telomere biology across species and propose specific measures for working with telomerase-deficient zebrafish.

Special Article

Key considerations to improve the normalization, interpretation and reproducibility of morbidity data in mammalian models of viral disease

Using findings from influenza-A-infected ferrets, Jessica Belser and colleagues discuss variability in the normalization, interpretation and presentation of morbidity measurements for four model species frequently used to study a diverse range of human viral pathogens.

Review

Stress in the metastatic journey – the role of cell communication and clustering in breast cancer progression and treatment resistance

Eloïse Grasset and colleagues examine the multiple challenges cancer cells encounter during metastasis and therapeutic interventions, with a focus on strategies adopted by cancer cells in the context of breast cancer.

Editor's choice

Tracking cell layer contribution during repair of the tympanic membrane by Olivia Dinwoodie, Abigail Tucker and Juan Fons

In this month’s Editor’s choice Research article, Juan Fons and colleagues follow the wound healing process after perforation of the tympanic membrane (i.e. the eardrum) in transgenic mouse models. Their results reveal the contribution of different germ layers during repair and highlight how defects might occur.

We summarize the findings of this study, highlighting its relevance to the development of targeted therapies in cases of acute and chronic eardrum perforation.

Also in this issue

MAP3K1 regulates female reproductive tract development

Transgenic C. elegans models of tauopathy

Targeted irradiation of murine pancreatic cancer

Cross-species modeling of muscular dystrophy in Caenorhabditis elegans using patient-derived extracellular vesicles

Journals from The Company of Biologists

Development current cover
Journal of Cell Science current cover
Journal of Experimental Biology current cover
Disease Models and Mechanisms current cover
Biology Open current cover
Close Modal

or Create an Account

Close Modal
Close Modal