... to its self-renewal activity and to its partnership with a conserved PUF RNA-binding protein. Intrinsically disordered region PUF RNA-binding protein PUF partnership Stem cell self-renewal Zinc finger Stem cell pool A central paradigm in stem cell biology is that niche signaling...

...Jakob V. Nielsen; Flemming H. Nielsen; Rola Ismail; Jens Noraberg; Niels A. Jensen Hippocampus-associated genes that orchestrate the formation of the compact stratum pyramidale are largely unknown. The BTB (broad complex, tramtrack,bric-a-brac)-zinc finger gene Zbtb20 (also known as HOF, Znf288...

... residues downstream of the second histidine residue of the second zinc finger(Fig. 3A), we conclude that the residues surrounding the C 2 H 2 zinc fingers are required for proper FOZI-1 function in the M lineage. The expression pattern of fozi-1 and the M lineage defects of fozi-1 mutants...

..., it is unclear how various subdivisions are established within the diencephalon - a complex integration center and relay station of the vertebrate brain. The conserved forebrain-specific zinc-finger-containing protein Fezl plays a crucial role in regulating neuronal differentiation in the vertebrate forebrain...

...Tsutomu Hirata; Masato Nakazawa; Osamu Muraoka; Rika Nakayama; Yoko Suda; Masahiko Hibi Fez and Fez-like (Fezl) are zinc-finger genes that encode transcriptional repressors expressed in overlapping domains of the forebrain. By generating Fez;Fezl -deficient mice we found that a redundant function...

...Tsutomu Hirata; Masato Nakazawa; Sei-ichi Yoshihara; Hitoshi Miyachi; Kunio Kitamura; Yoshihiro Yoshihara; Masahiko Hibi Fez is a zinc-finger gene encoding a transcriptional repressor that is expressed in the olfactory epithelium, hypothalamus, ventrolateral pallium and prethalamus at mid-gestation...

... remain regarding the mechanisms of specific target gene recognition and regulation, and the role of co-factors. From our studies of the gnathal and trunk-specification proteins Disconnected (DISCO) and Teashirt (TSH), respectively, we present evidence for a network of zinc-finger transcription factors...

... into domains – small intestine, large intestine and rectum – each characterized by a specific pattern of gene expression dependent upon normal drm and lin function. We show that drm encodes an 81 amino acid (10 kDa) zinc finger protein that is a member of the Odd-skipped family. drm expression is localized...

...Ruslan Dorfman; Lillian Glazer; Ulrich Weihe; Mathias F. Wernet; Ben-Zion Shilo The elbow (elB) gene encodes a conserved nuclear protein with a single zinc finger. Expression of ElB is restricted to a specific subset of tracheal cells, namely the dorsal branch and the lateral trunks. Stalled...

...Yalda Sedaghat; Wilson F. Miranda; Margaret J. Sonnenfeld We establish that the jing zinc-finger transcription factor plays an essential role in controlling CNS midline and tracheal cell differentiation. jing transcripts and protein accumulate from stage 9 in the CNS midline, trachea...

... studies indicated that rotund racGAP was not responsible for the rotund phenotypes and that the rotund gene had yet to be identified. We have isolated the rotund gene and show that it is a member of the Krüppel family of zinc finger genes. The adjacent roughened eye locus specifically affects the eye...

... and was dependent on the distal double GATA motif. Functional domain analyses using transgenic fish lines that harbor the gata1-GFP reporter construct revealed that both the N- and C-terminal zinc-finger domains of GATA1, hence intact GATA1 function, are required for the ectopic GFP expression. These results...

... functions in patterning the vegetal domain by suppressing animal regulatory activities. * Author for correspondence (e-mail: [email protected]) 17 11 2000 11 01 2000 © 2001 by Company of Biologists 2001 Sea urchin embryo β-Catenin Zinc finger Endoderm Morpholino...

...Gerard L. Campbell; Andrew Tomlinson ABSTRACT Members of the Hedgehog (HH) family of secreted signaling molecules specify cell fate during animal development by controlling the activity of members of the Gli family of zinc-finger transcription factors in responding cells. In Drosophila the Gli...

... to cooperate with these signals to confer correct context and competence for a cardiac cell fate. Additional factors are likely to be required for the appropriate specification of individual cell types within the forming heart. Similar to tinman , the zinc finger- and homeobox-containing gene, zfh-1...

... insight, the gene was cloned by chromosome walking. CRABS CLAW encodes a putative transcription factor containing a zinc finger and a helix-loop-helix domain. The latter resembles the first two helices of the HMG box, known to bind DNA. At least five other genes of Arabidopsis carry the same combination...

... aired -like) that resembles the Drosophila pair-rule gene odd-paired and encodes a zinc finger protein that is a member of the Zic gene family. At the onset of gastrulation, opl is expressed throughout the presumptive neural plate, indicating that neural determination has begun at this stage while...

... in these processes. In the frog neural plate, we have previously shown that the zinc finger transcription factor Gli1 is expressed in midline cells and mediates the effects of Shh inducing floor plate differentiation. In contrast, Gli2 and Gli3 are expressed throughout the neural plate except for the midline. Here...

... zinc fingers. Consistent with this sequence motif, crol mutations have stage-specific effects on ecdysone-regulated gene expression. The EcR ecdysone receptor, and the BR-C, E74 and E75 early regulatory genes, are submaximally induced in crol mutants in response to the prepupal ecdysone pulse...

... and differentiation of these lineages are largely unknown. Here we analyse mechanisms leading to cell differentiation within the NB 7-3 lineage. Analogous to the grasshopper, NB 7-3 is the progenitor of the Drosophila vNC serotonergic neurons. The zinc finger protein Eagle (Eg) is expressed in NB 7-3 just after...