... ovulation, a process that is highly conserved from flies to mammals. The factors that regulate spatiotemporal expression of MMP2 in follicle cells remain unknown. Here, we demonstrate crucial roles for the ETS-family transcriptional activator Pointed (Pnt) and its endogenous repressor Yan in the regulation...

... melanogaster anterior open Yan TEL1 ETS domain MAPK Wingless spalt Tracheal system Epithelial tube morphogenesis Angiogenesis Tip cell specification Tip cells are specialized endothelial cells that lead the migration of sprouting vessels and mediate anastomosis...

... of yan mutant lymph glands revealed that this transcriptional regulator promotes blood cell differentiation and the loss of prohemocyte maintenance. Expression of Bam or mir-7 in hematopoietic progenitors leads to a reduction of Yan protein. Together, these results demonstrate that Bam and mir-7...

... to understand and predict the bistable or multistable behavior of such networks. Fig. 5. The Yan network switch. Putative role of the Yan network as a bistable switch that regulates differentiation in the eye imaginal disc. (A) The Yan network consists of a group of regulators downstream of RTK signaling...

... stripe, we previously showed that Wingless, expressed just anterior to the Engrailed cells, is essential for the specification of anterior Engrailed cell fate. In a screen for additional mutations affecting Engrailed cell fate, we identified anterior open/yan , a gene encoding an inhibitory ETS-domain...

... of longitudinal glia to enwrap longitudinal axon tracts. DFR1 mutant phenotypes were partially mimicked by the targeted expression of activated Yan, thus demonstrating the MAP kinase pathway to be involved in differentiation of mesoderm. * Present address: National Institute for Basic Biology, Myodaijicho...

... of pntP1 , high levels of DER activity lead to inactivation of the Yan protein, a transcriptional repressor of Pointed-target genes. These two antagonizing transcription factors subsequently control the expression of secondary target genes such as otd, argos and tartan . The simultaneous effects of the DER...

...Ronald Rogge; Patricia J. Green; Jun Urano; Shirley Horn-Saban; Marek Mlodzik; Ben-Zion Shilo; Volker Hartenstein; Utpal Banerjee ABSTRACT An allele of the yan locus was isolated as an enhancer of the Ellipse mutation of the Drosophila epidermal growth factor receptor (Egfr) gene. This yan allele...