...Jake Turley; Francesca Robertson; Isaac V. Chenchiah; Tanniemola B. Liverpool; Helen Weavers; Paul Martin ABSTRACT One of the key tissue movements driving closure of a wound is re-epithelialisation. Earlier wound healing studies describe the dynamic cell behaviours that contribute to wound re...

... of stage 15 embryos demonstrated that wound healing was delayed in EGFR hypomorphic mutants (Geiger et al., 2011). Here, we chose to create a wound in the region requiring EGFR (ventral epidermis), i.e. at the left side of first thoracic segment in stage 11, where we would not see any defect in EGFR...

... in deciphering the molecular and cellular basis of wound healing, tissue repair and regeneration, as well as their implications for future clinical applications. The conference showcased an ever-expanding diversity of model organisms used to identify mechanisms that promote regeneration. Over 25 species were...

... al., 2021), but this remains inconclusive owing to the lack of efficient methods to isolate PDLCs and other cells from the PDL. Future studies should elucidate how pericytes and PDLCs repair tissues by interacting with immune cells at each stage of wound healing. Other cell types, such as plasma...

... Wnt Tagln Acta2 Gpr177 Colitis Wound healing Intestinal stem cell National Institutes of Health R01DK102934 R01DE026936 R01DE015654 R01DK119198 R01AT010243 The development and maintenance of intestinal epithelium depend on intact Wnt signaling. Removing β-catenin or Tcf4...

...Alan Y. Wong; Jessica L. Whited ABSTRACT Striking similarities between wound healing, epimorphic regeneration and the progression of solid tumors have been uncovered by recent studies. In this Review, we discuss systemic effects of tumorigenesis that are now being appreciated in epimorphic...

... injury. This observation hints towards a role for the Eda pathway in controlling the switch from basal to reflex tears, to support corneal wound healing. Collectively, our data suggest a crucial implication of Eda signaling in the cornea–lacrimal gland feedback loop, both in physiological...

... advances in wound healing, repair and regeneration. The meeting covered a wide range of regeneration models and tissues, identification of regulatory genes and signals, and striking advances toward regenerative therapies. Here, we report some of the exciting topics discussed during this conference...

... taken place. Further genetic analysis revealed that the activation of the initiator caspase Dronc is coupled with the generation of reactive oxygen species. The activation of Dronc also regulates myosin levels and delays wound healing. Our findings suggest a possible function for non-apoptotic caspase...

... inhibitory Wnt signaling via Wnt5a fosters endothelial differentiation of Nkx2.5 + cardiac progenitor cells during mouse embryogenesis and human pluripotent stem cell differentiation. Cardiac development Cardiac differentiation Wound healing Myocardial infarction Myocardial scar formation...

... and highlights the diversity of regeneration strategies in different organ systems and species. Cell plasticity and cell reprogramming Blastema dynamics Model systems Immune response Transcriptional control of regeneration Wound healing Injury-induced signaling Senescence and ageing Canton...

... by The Company of Biologists Ltd 2016 Summary: Inhibiting fibroblast migration during regeneration in axolotl reveals the importance of fibroblasts for blastema-based limb regeneration but not non-blastemal skin regrowth. Beryllium Regeneration Wound healing Limb development Ambystoma...

... cellular processes that take place both within the epidermis and in other participating tissues. Re-epithelialization of partial- or full-thickness skin wounds of adult zebrafish, however, is extremely rapid and largely independent of the other processes of wound healing. Live imaging after treatment...

... CEC stratification, differentiation and exfoliation (Fig. 4 B,C). To determine whether absence of Ift88 affects the process of CE wound healing, we performed a 1.5-mm epithelial abrasion and followed the wound closure by fluorescein staining. In a typical experiment, epithelial wound recovery occurred...

... is essential for: (1) general mRNA translation during embryogenesis, (2) developmental re-programming upon manipulations to the embryo and (3) larval wound healing. We also learned that Vasa interacted with mRNAs in the perinuclear area and at the spindle in an Importin-dependent manner during cell cycle...

... algorithms Wound healing Drosophila Epithelial tissues display an ability to repair wounds. This ability is remarkable in embryos, in which epidermal wounds heal rapidly, with little inflammation and no scarring (Rowlatt, 1979). The rapid embryonic response to wounds is conserved across species...

.../licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. Wound healing Drosophila embryo Actomyosin behaviour Throughout embryonic development, individual epithelial cells divide, stretch...

...Barbara A. Schmidt; Valerie Horsley Acute wound healing in the skin involves the communication of multiple cell types to coordinate keratinocyte and fibroblast proliferation and migration for epidermal and dermal repair. Many studies have focused on the interplay between hematopoietic cells...

... populations in the HF during wound healing. In particular, we demonstrate that Lhx2 promotes wound re-epithelization via positive regulation of Sox9 , and Tcf4 , while simultaneously inhibiting HF cycling via negative regulation of Lgr5 . Thus, Lhx2 serves as a key factor integrating signalling...

...,and inhibition of cell motility and in vitro wound healing. Although the rate of cell proliferation was reduced, terminal differentiation was unaffected. To assess the role of Necl2 in vivo, we examined the epidermis of Necl2 -null mice and developed transgenic mice that expressed Necl2 in the basal layer...