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Keywords: wnt8
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Journal Articles
Journal: Development
Development (2009) 136 (24): 4083–4088.
Published: 15 December 2009
... Crescent (Cres), which are members of the sFRP family, have the ability to regulate the diffusibility and signalling areas of the Wnt ligands Wnt8 and Wnt11. We found, using the Xenopus embryo, that Wnts do not diffuse effectively, whereas Frzb and Cres spread very widely. Interestingly, Frzb and Cres...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (23): 3903–3910.
Published: 01 December 2008
... underlying the NC-forming region has been proposed as a source of this second signal. Wnt8 and Fgf8a are expressed in this tissue around the time of NC induction and are therefore good candidate NC inducers. Loss-of-function studies indicate that both of these ligands are necessary to specify the NC; however...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (3): 479–489.
Published: 01 February 2007
... regulator of the pathway. Likewise, activation of Wnt/β-catenin signaling by overexpression of wnt8 increases proliferation of progenitor cells in the regenerating fin. By contrast, overexpression of wnt5b ( pipetail ) reduces expression of Wnt/β-catenin target genes,impairs proliferation of progenitors and...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (6): 1261–1272.
Published: 15 March 2005
..., the blastoderm margin of the gastrula embryo acts as a source of signal(s) involved in this process. We demonstrate that positioning of the MHB organizer is tightly linked to overall neuroectodermal posteriorization, and specifically depends on Wnt8 signaling emanating from lateral mesendodermal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2004) 131 (16): 3991–4000.
Published: 15 August 2004
... of Wnts in ventralizing embryos is less complete. Wnt8 is required for ventral patterning in both Xenopus and zebrafish; however, its mechanism of action remains unclear. We have used the zebrafish to address the requirement for Wnt8 in restricting the size of the dorsal organizer. Epistasis...
Journal Articles
Journal: Development
Development (2001) 128 (18): 3571–3583.
Published: 15 September 2001
... overexpression studies in chick, Xenopus , mouse and zebrafish implicate lateral/paraxial mesoderm in supplying the transforming influence, which is largely speculated to be a Wnt family member. We have analyzed the requirement for the specific ventrolaterally expressed Wnt8 ligand in the posteriorization of...