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Keywords: wnt1
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Journal Articles
Journal: Development
Development (2013) 140 (6): 1342–1352.
Published: 15 March 2013
...Jasmine Yang; Ashly Brown; Debra Ellisor; Erin Paul; Nellwyn Hagan; Mark Zervas Wnt1 -expressing progenitors generate midbrain dopamine (MbDA) and cerebellum (Cb) neurons in distinct temporal windows and from spatially discrete progenitor domains. It has been shown that Wnt1 and Lmx1a participate...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2012) 139 (9): 1662–1669.
Published: 01 May 2012
... of Wnt1, the posterior-ventral region of the embryo is severely altered during early gastrulation. Strikingly, at this time, nodal and its downstream target genes gsc and bra are expressed ectopically, extending posteriorly to the blastopore. They override the initial specification of posterior-ventral...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (10): 1717–1726.
Published: 15 May 2009
... of neurons does not seem to result from a defect in NCC specification as all the usual markers, with the exception of Msx1 , are expressed in the dorsal caudal-most NT as early as E4/HH24. However, Bmp4-Wnt1 signaling, which triggers trunk NCC delamination, is impaired in this region due to persistence...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (20): 3459–3470.
Published: 15 October 2008
...., Heinzmann, U., Beisker, W. and Wurst, W. ( 2004 ). Effects of Wnt1 signaling on proliferation in the developing mid-/hindbrain region. Mol. Cell. Neurosci. 26 , 101 -111. Prakash, N. and Wurst, W. ( 2006 ). Development of dopaminergic neurons in the mammalian brain. Cell Mol. Life Sci. 63 , 187...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2008) 135 (3): 441–450.
Published: 01 February 2008
...Alfonso Lavado; Oleg V. Lagutin; Guillermo Oliver The homeobox gene Six3 represses Wnt1 transcription. It is also required in the anterior neural plate for the development of the mammalian rostral forebrain. We have now determined that at the 15- to 17-somite stage, the prospective diencephalon...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (18): 3339–3348.
Published: 15 September 2007
...Lisa M. Galli; Tiffany L. Barnes; Stephanie S. Secrest; Tatsuhiko Kadowaki; Laura W. Burrus A long-term goal of developmental biology is to understand how morphogens establish gradients that promote proper tissue patterning. A number of reports describe the formation of the Wg (Wnt1) gradient...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (1): 89–98.
Published: 01 January 2006
... play a central role in the modulation of different brain functions and are associated with major neurological and psychiatric disorders. Despite the importance of these cells, the molecular mechanisms controlling their development are still poorly understood. The secreted glycoprotein Wnt1 is expressed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2005) 132 (4): 775–785.
Published: 15 February 2005
... in the vertebrate hindbrain, but the role of these cells is not known. We have investigated the function of the Wnt1 signalling molecule that is expressed by boundary and roof plate cells in the zebrafish hindbrain. Knockdown of wnt1 or of tcf3b , a mediator of Wnt signalling, leads to ectopic expression...
Journal Articles
Journal: Development
Development (2003) 130 (22): 5319–5330.
Published: 15 November 2003
... domain upon which the cerebellum fuses. Elimination or overgrowth of this isthmic domain in Wnt1 sw/sw and En1 +/Otx2lacZ mutant mice, respectively, impair cerebellar midline fusion. Because the isthmus-derived midline cerebellar domain displays a distinct expression pattern of genes involved in BMP...
Journal Articles
Journal: Development
Development (2003) 130 (10): 2275–2287.
Published: 15 May 2003
.... Additionally, we observed ectopic expression of Wnt1 in the embryonic roofplate organizer region and dorsal telencephalon. To determine the phenotypic consequences of such Wnt1 misexpression, we deleted a putative EMX2 DNA-binding site from the Wnt1 enhancer and used this to misexpress Wnt1 in the developing...
Journal Articles
Journal: Development
Development (2002) 129 (22): 5269–5277.
Published: 15 November 2002
...Eiji Matsunaga; Tatsuya Katahira; Harukazu Nakamura The isthmus is the organizing center for the tectum and cerebellum. Fgf8 and Wnt1 are secreted molecules expressed around the isthmus. The function of Fgf8 has been well analyzed, and now accepted as the most important organizing signal...
Journal Articles
Journal: Development
Development (2002) 129 (20): 4763–4772.
Published: 15 October 2002
...Isabel Olivera-Martinez; Sylvain Missier; Sandrine Fraboulet; Jacques Thélu; Danielle Dhouailly The chick dorsal feather-forming dermis originates from the dorsomedial somite and its formation depends primarily on Wnt1 from the dorsal neural tube. We investigate further the origin...
Journal Articles
Journal: Development
Development (2001) 128 (24): 4979–4991.
Published: 15 December 2001
... examined another gene expressed at the mes-met junction. Wnt1 is normally expressed across the entire mesencephalon at the four-somite stage and then in a narrow band anterior to the Fgf8 expression domain ( Fig. 3 E). In Otx2 hOtx1/hOtx1 mutants at the five-somite stage, Wnt1 was absent from...
Journal Articles
Journal: Development
Development (2001) 128 (21): 4165–4176.
Published: 01 November 2001
... expression domains positions the MHB. How the positional information is translated into activation of Pax2 , Wnt1 and Fgf8 expression during MHB establishment remains unclear. In zebrafish spiel ohne grenzen ( spg ) mutants, the MHB is not established, neither isthmus nor cerebellum form, the midbrain...
Journal Articles
Journal: Development
Development (2001) 128 (19): 3665–3674.
Published: 01 October 2001
... Xenopus Frizzled Wnt Wnt1 Frizzled 3 Neural crest PDZ domain Dishevelled GIPC Wnt1 was first identified as an oncogene activated by provirus insertion ( Nusse and Varmus, 1992 ). Subsequently, Wnt1 was shown to be a member of a family of secreted glycoproteins (Wnts) that regulate cell...