... the evolution of developmental and organismal complexity. Here, we review how animal models for core spliceosome components have provided insights into the role of splicing in vertebrate development, with a specific focus on neuronal, neural crest and skeletal development. To this end, we also discuss relevant...

... and a small fraction of genomic regions is hypomethylated. Previous studies have implicated hypomethylated regions in gene regulation, but their functions in vertebrate development remain elusive. To address this issue, we generated epigenomic profiles that include base-resolution DNA methylomes and histone...

... residues within the homeodomain. 9 5 2012 © 2012. 2012 Hox genes Axial patterning Transgenics Vertebrate development Mouse Hox genes are key regulators of embryonic development (Krumlauf, 1994 ; Pearson et al., 2005). Genes of this family are typically organized in genomic...

..., neural plate,. * Author for correspondence (e-mail: [email protected]) 30 08 2000 © 2000 by Company of Biologists 2000 FGF Pax6 Neural tube Patterning Vertebrate development Chick In the developing vertebrate central nervous system, the regionalised...

... indispensable and unique functions. The identification of these genes is a major issue in modern biological research. zebrafish ENU mutagenesis ‘Tübingen’ mutants’ vertebrate development © 1996 by Company of Biologists 1996 05 03 1996 †† Present address: Albert Einstein...

... in 43 % formamide and the washing was done at 42°Cin2×SSC. Copyright © 1988 by Company of Biologists 1988 paired box genes segmentation vertebrate development intervertebral disks With the isolation of several independent cDNA clones from mouse embryonic libraries, the presence...