...Leif R. Lund; Signe F. Bjørn; Mark D. Sternlicht; Boye S. Nielsen; Helene Solberg; Pernille A. Usher; Ruth Østerby; Ib J. Christensen; Ross W. Stephens; Thomas H. Bugge; Keld Danø; Zena Werb ABSTRACT Urokinase-type plasminogen activator expression is induced in the mouse mammary gland during...

...Hong-Ming Zhou; Anthony Nichols; Annelise Wohlwend; Isabelle Bolon; Jean-Dominique Vassalli By catalyzing plasmin formation, the urokinase-type plasminogen activator (uPA) can generate widespread extracellular proteolysis and thereby play an important role in physiological and pathological...

... was upregulated at day 2, when apoptotic cells were seen initially. Expression of the matrix metalloproteinases gelatinase A and stromelysin-1 and the serine proteinase urokinase-type plasminogen activator, which was low during lactation, was strongly upregulated in parallel starting at day 4 after weaning...

... metalloproteinase gelatinase B (MMP-9), urokinase-type plasminogen activator (uPA) and their inhibitors was investigated during early mouse embryo development. Transcripts for tissue inhibitors of metalloproteinases (TIMP-1,-2,-3) and uPA receptor were detected throughout pre- and peri-implantation develop-ment...

...Paul G. McGuire; Susan M. Alexander ABSTRACT The expression of the serine protease urokinase is elevated during the epithelial-mesenchymal transformation of the endocardium in the developing avian heart. Elevated urokinase expression is associated with the migrating mesenchymal cells...

...Y. Sumi; M. A. R. Dent; D. E. Owen; P. J. Seeley; R. J. Morris ABSTRACT Tissue and urokinase-type plasminogen activators are serine proteases with highly restricted specificity, their best characterised role being to release the broad specificity protease plasmin from inactive plasminogen. It has...

... not inhibit all of the caseinases. Urokinase was also secreted. Addition of TIMP at 5·500 nM effectively inhibited the degradation of matrix by the trophoblast outgrowths. Blocking antibodies directed against 92 × 10 3 M r gelatinase abolished matrix degradation by the trophoblast cells. These observations...