...Michael J. Murray; Catherine M. Davidson; Neil M. Hayward; Andrea H. Brand Fes/Fer non-receptor tyrosine kinases regulate cell adhesion and cytoskeletal reorganisation through the modification of adherens junctions. Unregulated Fes/Fer kinase activity has been shown to lead to tumours in vivo. Here...

...Françoise Helmbacher; Sylvie Schneider-Maunoury; Piotr Topilko; Laurent Tiret; Patrick Charnay ABSTRACT The Eph family of tyrosine kinase receptors has recently been implicated in various processes involving the detection of environmental cues such as axonal guidance, targeted cell migration...

... receptors are uniformly expressed along the dorsal-ventral retinal axis. This is in contrast to the previously reported high ventral-low dorsal gradient of EphB receptors later in development when RGC axons map to CNS targets. We show that mice lacking both EphB2 and EphB3 receptor tyrosine kinases...

...Kaushiki P. Menon; Kai Zinn ABSTRACT Tyrosine kinase signaling pathways are essential for process outgrowth and guidance during nervous system development. We have examined the roles of tyrosine kinase activity in programming growth cone guidance decisions in an intact nervous system in which...

... transcription factors governing this process, but little is known of how these relate to molecules mediating cell-cell signalling. The Eph receptor tyrosine kinase gene EphA4 ( Sek-1 ) is expressed in r3 and r5, and function- blocking experiments suggest that it is involved in restricting intermingling of cells...

... gene torso receptor tyrosine kinase neuroblast fate brain development transcription factor regulatory module Expression of the Drosophila tailless ( tll ) gene provides an instructive example of what has now become a generally accepted principle: many developmental regulatory genes...

... kinase neuropeptide sensory neuron During vertebrate development, many peripheral neurons depend for their survival on neurotrophins synthesised by the tissues that they innervate ( Davies, 1994a ). The effects of neurotrophins are mediated by the Trk family of receptor tyrosine kinases...

...Makoto Koga; Yasumi Ohshima ABSTRACT The let-23 receptor tyrosine kinase gene is required for vulval induction and larval survival in the nematode Caenorhabditis elegans . We carried out genetic mosaic analyses of the let-23 gene function by using the cloned let-23 and ncl-1 genes. The wild-type...

... did not affect intracellular Ca 2+ levels but did induce cortical contraction. Tyrosine kinase inhibitors (tyrphostin and staurosporine) suppressed the Mg 2+ -induced Ca 2+ rise and contraction, and the inhibition could be overcome by injection with inositol 1,4,5-trisphosphate. Immunoprecipitation...

...Lino Tessarollo; Pantelis Tsoulfas; Dionisio Martin-Zanca; Debra J. Gilbert; Nancy A. Jenkins; Neal G. Copeland; Luis F. Parada ABSTRACT The Trk family of tyrosine kinases encodes receptors for nerve growth factor-related neurotrophins. Here we present a developmental expression study of trk C...

... to vertebrate FGF-receptor genes. DFR1 and DFR2 proteins contain two and five immunoglobulin-like domains, respectively, in the extracellular region, and a split tyrosine kinase domain in the intracellular region. In early embryos, DFR1 RNA expression, requiring both twist and snail proteins, is specific...

... that of XFGFR-1. * Author for correspondence 14 09 1992 © 1992 by Company of Biologists 1992 Xenopus FGF receptor gene expression tyrosine kinase Recent experimental evidence indicates that the protein tyrosine kinases (PTKs) have a prominant role in developmental...

... Pleurodeles FGF receptors that share characteristics common to members of the FGF receptor superfamily. The deduced amino acid sequence of PFR1 is 85% identical overall with the human fms-like-gene (FLG). PFR4 is most closely related to the human FGFR-4 (66% overall identity). The tyrosine kinase catalytic...

...Lino Tessarollo; Lalitha Nagarajan; Luis F. Parada The c-ros proto-oncogene is the vertebrate homologue of the Drosophila sevenless tyrosine kinase receptor. Examination of c-ros mRNA transcripts in the mouse embryo reveals a stringent pattern of expression. Only kidney, intestine and lung exhibit...

...Rüdiger Klein; Dionisio Martin-Zanca; Mariano Barb Acid; Luis F. Parada We have examined the expression of the trk B gene, which encodes a member of the family of protein tyrosine kinase (TK) transmembrane receptors, during mouse embryogenesis using in situ hybridization and Northern analysis...