... of the NF1 gene as a tumor suppressor gene, loss of heterozygosity at the NF1 locus and loss of neurofibromin expression have been observed in a variety of NF1-associated tumors, including astrocytomas( Gutmann et al., 2000 ; Kluwe et al., 2001 ). In one case report, loss of neurofibromin expression...

...Nathalie Arquier; Laurent Perrin; Pascal Manfruelli; Michel Sémériva The Drosophila tumor suppressor gene lethal(2) giant larvae ( lgl ) encodes a cytoskeletal protein required for the change in shape and polarity acquisition of epithelial cells, and also for asymmetric division of neuroblasts...

... . * Author for correspondence † Deceased in April 1994 19 04 1996 © 1996 by Company of Biologists 1996 Drosophila tumor suppressor gene cell shape cytoskeleton A mutant animal deficient for the gene l(2)gl develops tumors that appear at the end of the third instar...