...Mycah T. Sewell; Emilie Legué; Karel F. Liem, Jr ABSTRACT Cilia are microtubule (MT)-based organelles present on the surface of nearly all vertebrate cells. MTs are polymers of α- and β-tubulins that are each encoded by multiple, individual isotype genes. Tubulin isotype composition is thought...

...-confidence autism spectrum disorder (ASD) risk genes highlight chromatin regulation and synaptic function as major contributors to pathobiology. Our recent functional work in vivo has additionally implicated tubulin biology and cellular proliferation. As many chromatin regulators, including the ASD risk...

... in the constituents of microtubules, the tubulins, are known to cause an array of neurological disorders, including lissencephaly, polymicrogyria and microcephaly. In this study we explore the genetic and cellular mechanisms that cause TUBB5-associated microcephaly by exploiting two new mouse models: a conditional...

...Kathleen A. Matthews; Dianne Rees; Thomas C. Kaufman ABSTRACT Three α-tubulin proteins contribute to microtubules during oogenesis and early embryogenesis in Drosophila melanogaster : αTUB84B, αTUB84D, and αTUB67C. αTUB67C is unique in two respects. It is a structurally divergent α-tubulin, sharing...

... of tubulin network was not uniform, but disposed in zebra stripes. Antibodies against α-tubulin showed 14 alternating pairs of darker and brighter transverse areas. The possible significance of this pattern is discussed. 24 05 1989 © 1989 by Company of Biologists 1989 Drosophila early...

...Zhiyuan Gong; Bruce Brandhorst When pluteus embryos of Lytechinus pictus were treated with colcemid, the incorporation of [ 35 S]meth- ionine into tubulin declined by 5- to 15-fold within 4 h. This was mostly accounted for by a rapid decline in the concentration of α - and β -tubulin mRNA...

..., and may be lineage related. Copyright © 1985 by Company of Biologists 1985 oocyte oogenesis actin tubulin vimentin cytokeratin cytoplasmic determinants germ plasm Xenopus laevis It is clear from many experiments on diverse animal species that regional and cell lineage...

...Jiří Paleček; Věra Habrová; Josef Nedvídek; Alexej Romanovský ABSTRACT The distribution of tubulin and/or tubulin-containing structures was examined in separate classes of Xenopus laevis oocytes and in germinal vesicles isolated from them. Although a monoclonal antibody has been used, the technique...