...-mediated signaling through Trk tyrosine kinase receptors is important for embryonic cortical precursor cell development. These studies demonstrate that inhibition of TrkB (Ntrk2)and/or TrkC (Ntrk3) signaling using dominant-negative Trk receptors, or genetic knockdown of TrkB using shRNA, caused a decrease...

... development, we first examined the expression of neurotrophic factor receptors in the LC. TrkB, TrkC, GFRα1,GFRα2 and Ret mRNA expression was analyzed in the mouse LC by in situ hybridization at four developmental stages (E13, E15, E17 and P0). In situ hybridization was performed with a specific TH riboprobe...

... counted the total number of neurons, using NeuN as a marker, the number of GAD65 (Gad2), TrkB (Ntrk2) and TrkC (Ntrk3) mRNA expressing neurons, the CB- and PV-immunoreactive neurons, and the proportion of CB- and PV-immunoreactive neurons expressing GAD65, TrkB and TrkC mRNA. The overlap of GAD65 and TrkB...

.... However, it is not yet clear when, and in what order, crest cells become specified to adopt a particular fate. We report that the receptor tyrosine kinases TrkC and C-Kit are expressed by distinct neural crest subpopulations in vitro. We then analyzed the lineages of individual receptor-expressing crest...

... (NT3) ablation in mice causes a more severe neuronal phenotype than deletion of its receptor TrkC, suggesting that NT3 acts also through other non-preferred Trk receptors. To study the role of low-affinity ligand receptor interactions in vivo, we have replaced the Nt3 gene with the gene for brain...

..., reflecting a profound deafness. DiI fiber staining, immunostaining and cell death assays reveal that the deafness is due to the failure of inner ear sensory neuron survival during development. The affected inner ear sensory neurons fail to express neurotrophin receptors, TrkB and TrkC, suggesting...

...Thomas Schimmang; Liliana Minichiello; Esther Vazquez; Isabel San Jose; Fernando Giraldez; Rüdiger Klein; Juan Represa ABSTRACT The trkB and trkC genes are expressed during the formation of the vestibular and auditory system. To elucidate the function of trkB and trkC during this process, we have...

... sclerotome somite trkC The transformation of epithelial cells into mesenchyme is a basic process in embryonic morphogenesis. The paraxial mesoderm, composed of metamerically arranged somites, provides a good model system to investigate these phenotypic conversions. The epithelial somites dissociate...

... period of sensory neuron death in vivo. * Author for correspondence 15 02 1995 © 1995 by Company of Biologists 1995 neurotrophin-3 muscle spindle afferents cutaneous afferents motoneurons trkC cell death During normal embryonic development, approximately half...

...., 1991 ) and forms part of the high affinity NGF receptor ( Klein et al., 1991 ; Hempstead et al., 1991 ). Furthermore, the NGF-related neurotrophins have been identified as ligands for the Trk -related RTK-encoding genes trkB and trkC ( Berkemeier et al., 1991 ; Ip et al 1992 ; Soppet et al...