....tb17701.x Mishima , Y. and Tomari , Y. ( 2016 ). Codon usage and 3′ UTR length determine maternal mRNA stability in zebrafish . Mol. Cell 61 , 874 - 885 . 10.1016/j.molcel.2016.02.027 Nagorska , A. ( 2022 ). Translational control of left right patterning by a 3′UTR...

..., depletion of eef1a1l2 in nanog mutant females effectively rescued the elevated translational activity in oocytes, oogenesis defects and embryonic defects of M nanog embryos. Thus, our study demonstrates that maternal Nanog regulates oogenesis and early embryogenesis through translational control of maternal...

... Oogenesis p53 Zebrafish Translational control ER stress Unfolded protein response Apoptosis Sex differentiation In contrast to spermatogenesis, oogenesis is associated with increasing cell volume and accumulating maternal molecules such as RNAs and proteins, which are essential for oogenesis...

... Ltd 2015 Summary: The translation timing of Cyclin B1 RNA during meiotic prophase in the male Drosophila germline is regulated by two interacting proteins, Rbp4 and Fest. Drosophila Spermatogenesis Meiosis Cyclin B Translational control Meiosis, the pair of specialized...

... ). Molecular mechanisms of mTOR-mediated translational control . Nat. Rev. Mol. Cell Biol. 10 , 307 - 318 . Malumbres M. , Barbacid M. ( 2003 ). RAS oncogenes: the first 30 years . Nat. Rev. Cancer 3 , 459 - 465 . McCubrey J. A. , Steelman L. S. , Chappell W. H...

... © 2012. Male meiosis Cytokinesis Translational control Fertility Translational control plays a crucial role during development when transcription is quiescent or when asymmetric localization of proteins needs to be established, such as in early embryogenesis, neurogenesis...

... in promoting fast-twitch-specific fate by repressing the slow-twitch differentiation pathway ( von Hofsten et al., 2008 ). Sox6 Translational control miR-499 ( mir499 ) Muscle fibre type Zebrafish Prdm1 © 2011. 10 8 2011 Competing interests statement The authors...

... beyond transport at the nuclear pore to include mRNA regulation in the cytoplasm. C. elegans Nup98 P granule Germline Nucleoporin Translational control Germ cells contain unique cytoplasmic organelles called germ granules ( Saffman and Lasko, 1999 ). Germ granules are rich in RNA...

... specifically required for different steps of oogenesis. * Author for correspondence (e-mail: [email protected] ) 8 4 2008 © 2008. 2008 Cytoplasmic polyadenylation Drosophila GLD-2 Meiosis Metaphase I Translational control In many species, the oocyte and early...

... is the earliest known molecular event specific to the germline founder cell P 4 . Cis-elements in nos-2 3′UTR have been shown to mediate translational control; however, the trans-acting proteins are not known. Here, we provide evidence that four maternal RNA-binding proteins, OMA-1, OMA-2, MEX-3 and SPN-4, bind...

...Catherine C. Baker; Margaret T. Fuller Translational control is crucial for proper timing of developmental events that take place in the absence of transcription, as in meiotic activation in oocytes, early embryogenesis in many organisms, and spermatogenesis. Here we show that a novel form...

... Translational control Polyadenylation Mouse Early animal development is programmed by maternally inherited mRNAs that are synthesized during oogenesis ( Wickens et al., 2000 ; Richter,2000 ). These mRNAs are translated during oocyte maturation, when the cell enters the meiotic divisions, and during...

... activation of nanos mRNA localized at the posterior pole. Two mechanisms of nanos translational repression have been described, at the initiation step and after this step. Here we identify a novel level of nanos translational control. We show that the Smaug protein bound to the nanos 3′ UTR recruits...

.... * These authors contributed equally to this work 15 6 2006 © 2006. 2006 † Author for correspondence (e-mail: [email protected] ) Caenorhabditis elegans Vulva Pumilio Translational control Signal transduction The spatial and temporal regulation of gene expression can...

...Kevin M. Forrest; Ira E. Clark; Roshan A. Jain; Elizabeth R. Gavis Translational control of gene expression plays a fundamental role in the early development of many organisms. In Drosophila , selective translation of nanos mRNA localized to the germ plasm at the posterior of the embryo, together...

...Darcy Mootz; Diana M. Ho; Craig P. Hunter Translational control is an essential mechanism of gene control utilized throughout development, yet the molecular mechanisms underlying translational activation and repression are poorly understood. We have investigated the translational control of the C...

... and skn-1 , as well as apx-1 . The NRE-like motif is found in apx-1 and pal-1 3′ UTRs, but not in skn-1 . Work is in progress to examine whether these motifs are functionally important for the translational control. POS-1 and SPN-4 may change their function depending on the target mRNAs...

... for correspondence (e-mail: [email protected] ) 24 4 2002 © 2002. 2002 Translational control mRNPs Protamine Spermatogenesis RNA-binding Mouse Post-transcriptional control is a major form of gene regulation during mammalian gametogenesis. In haploid spermatids, proteins required...

...Ira E. Clark; Krista C. Dobi; Heather K. Duchow; Anna N. Vlasak; Elizabeth R. Gavis Translational repression of maternal nanos ( nos ) mRNA by a cis -acting Translational Control Element (TCE) in the nos 3′UTR is critical for anterior-posterior patterning of the Drosophila embryo. We show, through...

... and Pumilio. Curr. Biol . 10 , R81 -R83. Richter, J. ( 1996 ). Dynamics of polyA addition and removal during development. In Translational Control (ed, J. Hershey, M. Mathews and N. Sonenberg), pp. 481-503. New York: Cold Spring Harbor Laboratory Press. Richter, J. ( 2000 ). Influence...