...Peter Koopman; Andrew Sinclair; Robin Lovell-Badge ABSTRACT On Thursday 9 May 1991, the world awoke to front-page news of a breakthrough in biological research. From Washington to Wollongong, newspapers, radio and TV were abuzz with the story of a transgenic mouse in London called Randy. Why...

.... † Author for correspondence (e-mail: [email protected] ) * These authors contributed equally to this study 12 8 2008 © 2008. 2008 Kidney development RhoA ROCK Epithelial-mesenchymal interaction Transgenic mouse During the development of organs...

... in a male germ cell deficiency, irrespective of the co-expression of Nanos3 in these cells. These results indicate that these two Nanos proteins have distinct functions, which depend on the time and place of their expression. To further elucidate this, we have generated transgenic mouse lines that express...

.... * Author for correspondence (e-mail: [email protected] ) 5 8 2004 © 2004. 2004 BMP Msx2 Homeodomain Smad Transcription Transgenic mouse Evolution A striking property of morphogens is that they act through a small number of signaling pathways, yet elicit a wide variety...

... regulators controlling outflow tract and right ventricle development. * Author for correspondence (e-mail: [email protected] ) 6 5 2004 ©2004. 2004 Mef2c transgenic mouse cardiac development transcription secondary heart field anterior heart field ISL1 (ISL-1) GATA4...

[email protected] ) 10 11 1999 12 01 2000 © 2000 by Company of Biologists 2000 TGFα EGF EGF Receptor Corneal endothelial cell Anterior segment dysgenesis Eye Transgenic mouse In mouse, the development of the anterior segment of the eye begins at about embryonic day 11 (E11...

... of reduced osteoclast activity was found in transgenic mouse skulls, which had less cavitation and fewer mature osteoclasts relative to skulls of wild-type mice. These bone remodeling defects resulted in altered biomechanical properties. The femurs of transgenic mice were tougher, and their vertebral bodies...

... (TGF-β3) Transgenic mouse Filopodia Lamellipodia Cell adhesion molecules Organ culture © 1999 by Company of Biologists 1999 1 6 1999 5 8 1999 * Author for correspondence (e-mail: [email protected] ) ...

... of the MEF2 sites and flanking sequences from the desmin and c-jun genes. To monitor the expression of functional MEF2 factors during mouse embryogenesis, we created transgenic mouse lines harboring a lacZ reporter gene linked to the hsp 68 gene promoter and three tandem copies of the MEF2 site...

... in mouse embryos. To elucidate the cis control mechanisms that regulate MyoD transcription, we have mutagenized the entire core enhancer using linker-scanner mutagenesis, and have tested the transcriptional activity of enhancer mutants using lacZ reporter gene expression in transgenic mouse embryos...

... is known about the underlying molecular mechanisms that control these aspects of neural crest patterning and development. Neural crest Hoxa2 AP-2 Transgenic mouse Gene regulation © 1999 by Company of Biologists 1999 08 01 1999 ‡ Author for correspondence (e-mail: r...

[email protected] ) 22 05 1998 © 1998 by Company of Biologists 1998 Kit steel factor Melanocyte development Melanoblast Transgenic mouse c-Kit The c-Kit receptor tyrosine kinase of the mouse and its ligand, steel factor (SLF), are encoded by the dominant white spotting ( Kit...

... 31 10 1996 © 1997 by Company of Biologists 1997 Pax3 P19 embryonal carcinoma transgenic mouse DNA sequence elements enhancer transcriptional regulatory elements dorsoventral patterning Pax3 is one of nine members of a family of transcription factors that have...

... Institute of Biomolecular Medicine, 540 First Avenue, New York, NY 10016, USA 30 05 1996 © 1996 by Company of Biologists 1996 sonic hedgehog cAMP-dependent protein kinase A CNS patterning transgenic mouse The notochord has been known for some time to act as the source...

... differentiation. * Author for correspondence (e-mail: [email protected] ) 17 06 1996 © 1996 by Company of Biologists 1996 mammary gland galactosyltransferase morphogenesis transgenic mouse mouse Mammary gland morphogenesis begins during fetal development...

.... * Author for correspondence 18 02 1994 © 1995 by Company of Biologists 1995 in ovo transplantation mouse somite graft desmin transgenic mouse chimera In vertebrates, skeletal muscle is derived from somites that develop by segmentation of the paraxial mesoderm. In the mouse...

... us to deliver genes specifically into this cell type in vivo to test specifically molecules that have been implicated in cardiovascular development. Furthermore, we have established embryonic stem (ES) cells from the blastocysts of the transgenic mouse that carry the 1.2 kb promoter-LacZ reporter...

... endocrine cells, which migrated to form clusters with other differentiating endocrine cells. * Author for correspondence 11 03 1994 © 1994 by Company of Biologists 1994 amylase carbonic anhydrase II (CA II) intermediate cell pancreatic duct islet regeneration transgenic mouse...

... Laboratories, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA 22 02 1994 © 1994 by Company of Biologists 1994 neural development Wnt family spinal cord transgenic mouse cell signalling cell proliferation pattern formation The vertebrate central nervous...

... Washington Street, Box 218, Boston, MA 02111, USA 28 10 1993 © 1994 by Company of Biologists 1994 peptide YY islet cell lineage transgenic mouse pancreas The embryonic pancreatic duct arises from primitive gut endoderm and contains endocrine precursor cells from which...