... Transgenic Mice Melanocyte Cell migration requires precise coordination of cell attachment to the surrounding extracellular matrix (ECM) ( Devreotes and Horwitz, 2015 ). To allow efficient migration, cells must rapidly form new adhesions to the underlying substrate and then, in a carefully timed...

... for their technical assistance; Mei Zhang and Patricia Lee for animal care; Venkatesh Murthy for the Kir2.1 cDNA; and Wanda Filipiak and the Transgenic Animal Model Core of the University of Michigan for generation of transgenic mice. Author contributions E.M.J.-V., M.A.S. and H.U. designed...

... Germline Transgenic mice Parthenogenesis Haploid embryonic stem cells (ESCs) have recently been established following chemical activation of unfertilised mouse eggs ( Elling et al., 2011 ; Leeb and Wutz, 2011 ). Haploid parthenogenetic ESCs can be maintained as lines through flow cytometric...

...-mail: m.wegner@biochem.uni-erlangen.de ) 27 11 2007 © 2008. 2008 Sry High-mobility group Redundancy SoxE PDGF Glia Transgenic mice Rapid saltatory conductance in the vertebrate nervous system relies on the presence of myelinating glia and the formation of myelin sheaths...

...,including cerebral hemorrhages and altered cortical development. The cellular and molecular basis for the developmental effects of Psen1 remain incompletely understood. Psen1 is expressed in neural progenitors in developing brain, as well as in postmitotic neurons. We crossed transgenic mice with either...

... ). Despite this significance, relatively little is known about the mechanisms underlying CP development. Roof plate Fate map Genetic ablation Bmp Gdf7 Transgenic mice Cre recombinase Diphtheria toxin Mouse ©2005. 2005 23 5 2005 * Author for correspondence (e-mail: emonuki...

... EC1V 9EL, UK 2 2 2005 ©2005. 2005 Astrocytes Retina Blood vessels PDGF-A Oxygen Transgenic mice Proliferation of cultured cells was assessed by adding BrdU to culture medium (final concentration 10 μM) two hours before cells were fixed with 2% PFA in PBS. Retinal...

... in human breast tumors. However, the role of MTA1 in tumorigenesis in a physiologically relevant animal system remains unknown. To reveal the role of MTA1 in mammary gland development, transgenic mice expressing MTA1 under the control of the mouse mammary tumor virus promoter long terminal repeat were...

..., the cerebellum represents an ideal model system to analyze the impact of oligodendrocyte ablation on neighboring cells. MBP-TK transgenic mice expressing the HSV1-TK gene under the control of a 1.3 kb fragment of the myelin basic protein (MBP) promoter were used in this study. The MBP-TK transgene...

... for correspondence (e-mail: thomas.theil@uni-duesseldorf.de ) 12 4 2002 © 2002. 2002 Transgenic mice Gli 3 Wnt Bmp Emx Forebrain The embryonic dorsal telencephalon of vertebrates gives rise to the cerebral cortex, which, as the seat of consciousness and higher cognition...

...., Ariza-McNaughton, L., Muchamore, I., Kuroiwa, A. and Krumlauf, R. ( 1995 ). Comparative analysis of chicken Hoxb-4 regulation in transgenic mice. Mech. Dev . 53 , 47 -59. Nieto, M. A., Bradley, L. C. and Wilkinson, D. G. ( 1991 ). Conserved segmental expression of Krox-20...

... and Cdk4 activity, while Msx1 has minimal effects on cellular proliferation. Transgenic mice that express Msx1 under the control of the mouse mammary tumor virus long terminal repeat (MMTV LTR) display impaired differentiation of the mammary epithelium during pregnancy, which is accompanied by elevated...

... demonstrated to be necessary for endogenous initiation of fiber cell differentiation. To test this possibility, we have generated transgenic mice with ocular expression of secreted self- dimerizing versions of FGFR1 (FR1) and FGFR3 (FR3). Expression of FR3, but not FR1, leads to an expansion of proliferating...

... to maximize developmental competence of oocytes. * Author for correspondence (e-mail: tr44x@nih.gov ) 11 01 2001 13 03 2001 © 2001 by Company of Biologists 2001 Zona pellucida Fertilization Embryonic stem cells Sperm-egg interactions Transgenic mice Folliculogenesis Pre...

...@pasteur.fr ) 04 08 2000 © 2000 by Company of Biologists 2000 Myf5 Transcriptional regulation YACs Transgenic mice The myogenic regulatory factors (MRFs), Myf5, MyoD (Myod1; Mouse Genome Informatics), myogenin and Mrf4 (Myf6; Mouse Genome Informatics), are transcriptional...

... neurogenesis in a well-defined cell lineage. * Author for correspondence (e-mail: d-engel@northwestern.edu ) 09 08 2000 21 06 2000 © 2000 by Company of Biologists 2000 GATA2 V2 interneuron Transgenic mice The pervasive central question in embryology is how determined...

...Meei-Hua Lin; Cornelia Leimeister; Manfred Gessler; Raphael Kopan ABSTRACT Little is known about the mechanisms underlying the generation of various cell types in the hair follicle. To investigate the role of the Notch pathway in this process, transgenic mice were generated in which an active form...

... conditional reporter (R26R) Tooth formation Transgenic mice Wnt1 promoter In this study, we have systematically followed the lineage of CNC cells as they contribute to tooth and mandibular morphogenesis. At E11.5 (before the initiation of tooth formation) and E12.5 (when the dental lamina...

... virus was used to overexpress the human LEF1 gene in a human bronchial xenograft model of regenerative gland development in the adult airway. In a second model, the LEF1 gene was ectopically overexpressed under the direction of the proximal airway-specific CC10 promoter in transgenic mice. In both...

... acquired distinct functions during evolution. * Author for correspondence (e-mail: Urban.Lendahl@cmb.ki.se ) 05 08 1999 09 06 1999 © 1999 by Company of Biologists 1999 Lateral inhibition Stem cell Progenitor cell Transgenic mice Nervous system The Notch...