... in the germline is established by this time. Experiments where the sex of the soma was altered relative to that of the germline (by manipulating transformer) reveal a dominant role for the soma in regulating initial germline sexual identity. Germ cells largely take on the sex of the surrounding soma, although...

...Attilio Pane; Marco Salvemini; Pasquale Delli Bovi; Catello Polito; Giuseppe Saccone The medfly Ceratitis capitata contains a gene (Cctra) with structural and functional homology to the Drosophila melanogaster sex-determining gene transformer (tra) . Similar to tra in Drosophila , Cctra...

...Clemens Kiecker; Christof Niehrs Anteroposterior (AP) patterning of the vertebrate neural plate is initiated during gastrulation and is regulated by Spemann’s organizer and its derivatives. The prevailing model for AP patterning predicts a caudally increasing gradient of a ‘transformer’ which...

... early oogenesis. In particular, the sex-specific germline activity of the ovarian tumor promoter was found to be dependent upon somatic factors controlled by the somatic sex differentiation gene transformer . This regulation defines whether there is sufficient ovarian tumor expression in adult XX germ...

... © 1995 by Company of Biologists 1995 sex-specific splicing genetic mosaics msl genes transformer Drosophila virilizer The primary signal for sex determination in Drosophila melanogaster is the ratio of X chromosomes to sets of autosomes (X:A). This signal acts on the sex...

... host. In first instar larvae with two X chromosomes, XX germ cells enter the female or the male pathway depending on the presence or absence of transformer (tra) activity in the surrounding soma. In somatic cells, the product of tra regulates the expression of the gene double sex (dsx) which can form...