... Lymphatic endothelial cell Transcription factor Zebrafish Knut och Alice Wallenbergs Stiftelse http://dx.doi.org/10.13039/501100004063 2017.0144 Ragnar Söderbergs stiftelse http://dx.doi.org/10.13039/100007459 M13/17 Vetenskapsrådet http://dx.doi.org/10.13039...

... and cleft lip and/or palate. The highly conserved transcription factor grainyhead-like 2 (Grhl2) is a crucial regulator of tissue fusion, with mouse models lacking GRHL2 function presenting with a fully penetrant open cranial neural tube, facial and abdominal clefting (abdominoschisis), and an open...

...Eugene E. Kim; Akshay Shekhar; Jayalakshmi Ramachandran; Alireza Khodadadi-Jamayran; Fang-Yu Liu; Jie Zhang; Glenn I. Fishman ABSTRACT Reciprocal interactions between non-myocytes and cardiomyocytes regulate cardiac growth and differentiation. Here, we report that the transcription factor Ebf1...

..., and they create opportunities for diverse developmental strategies to emerge between species. To study the contribution of duplicated genes to human early development, we examined the evolution and function of NANOGP1 , a tandem duplicate of the transcription factor NANOG . We found that NANOGP1 and NANOG have...

...Katharine A. Hubert; Deneen M. Wellik ABSTRACT Hox genes encode evolutionarily conserved transcription factors that are essential for the proper development of bilaterian organisms. Hox genes are unique because they are spatially and temporally regulated during development in a manner...

.... Here, we demonstrate that a restricted pool of progenitors in the mouse spinal cord, expressing the transcription factor Dbx1, produces a subset of astrocytes, in addition to interneurons. Ventral p0-derived astrocytes (vA0 cells) exclusively populate intermediate regions of spinal cord...

... and glutamatergic neurons that have been associated with a variety of functions, including sleep regulation. However, the molecular characteristics and development of MRF neurons are poorly understood. As the transcription factor, Gata2 is required for the development of all GABAergic neurons derived from...

... of transcription factors with a mutually repressive relationship. The mechanism by which Dlx1/2 repress progenitor and oligodendrocyte fate, while promoting transcription of genes needed for differentiation, is not fully understood. We identified a motif within DLX1 that binds RBBP4, a NuRD complex subunit. ChIP...

... in response to various environmental cues, but the transcriptional machinery controlling beige adipocyte development and thermogenesis remains largely unknown. By analyzing beige adipocyte-specific knockout mice, we identified a transcription factor, forkhead box P4 (FOXP4), that differentially governs beige...

... the intervening region, referred to as the maxillomandibular junction (the hinge), maintains separation of the mandibular and maxillary domains. One cap signal is GATA3, a member of the GATA family of zinc-finger transcription factors with a distinct expression pattern in the ventral-most part of the mandibular...

... work is properly attributed. Highlighted Article: A transcriptome atlas of Arabidopsis embryos constructed from single nuclei reveals cell-specific epigenetic and transcriptional regulatory features. Arabidopsis Embryo Single-nucleus RNA-seq Gene expression Transcription factor...

...Izumi Oda-Ishii; Deli Yu; Yutaka Satou ABSTRACT Zic-r.a, a maternal transcription factor, specifies posterior fate in ascidian embryos. However, its direct target, Tbx6-r.b , does not contain typical Zic-r.a-binding sites in its regulatory region. Using an in vitro selection assay, we found...

... defects. Here, we propose the first developmental stage-specific network approach by integrating two crucial regulators, transcription factors (TFs) and microRNAs (miRNAs), to study their co-regulation during craniofacial development. Specifically, we used TFs, miRNAs and non-TF genes to form feed-forward...

... transcription factors in invertebrates, but only a few examples of such regulators have been provided in vertebrates. We hypothesised that TCF7L2 regulates different stages of postmitotic differentiation in the thalamus, and functions as a thalamic terminal selector. To investigate this hypothesis, we used...

...Candace S. Y. Chan; Nicolas Lonfat; Rong Zhao; Alexander E. Davis; Liang Li; Man-Ru Wu; Cheng-Hui Lin; Zhe Ji; Constance L. Cepko; Sui Wang ABSTRACT Transcription factors (TFs) are often used repeatedly during development and homeostasis to control distinct processes in the same and/or different...

...Markus Nevil; Tyler J. Gibson; Constantine Bartolutti; Anusha Iyengar; Melissa M. Harrison ABSTRACT The dramatic changes in gene expression required for development necessitate the establishment of cis- regulatory modules defined by regions of accessible chromatin. Pioneer transcription factors...

... photoreceptor CREs from wild-type and mutant mouse retinas, defined by presence or absence, respectively, of the rod-specific transcription factor (TF) Nrl . Nrl -dependent ncRNA expression strongly correlated with epigenetic profiles of rod and cone photoreceptors, identified thousands of candidate rod...

... lifespan in mammals. An oocyte-specific transcription factor cascade controls oocyte development, and some of these transcription factors, such as newborn ovary homeobox gene ( NOBOX ), are candidate genes for primary ovarian insufficiency in women. Transcription factors are frequently modified by the post...

...Orkan Ilbay; Victor Ambros ABSTRACT MicroRNAs target complementary mRNAs for degradation or translational repression, reducing or preventing protein synthesis. In Caenorhabditis elegans , the transcription factor HBL-1 (Hunchback-like 1) promotes early larval (L2)-stage cell fates, and the let-7...

... the molecular mechanisms modulating the selectivity of genomic targeting for the BAF chromatin remodeling complex. BAF SWI/SNF Chromatin DNA RNA Histone Transcription factor A complex higher organism, such as a human being, comprises a myriad of morphologically and functionally distinctive...