... to activate MYC transcription. Psi, the sole FUBP protein in Drosophila , binds RNA to regulate P-element and mRNA splicing. Our previous work revealed pro-growth functions for Psi, which depend, in part, on transcriptional activation of Myc. Genome-wide functions for FUBP family proteins in transcriptional...

...Gianluca Zambanini; Anna Nordin; Mattias Jonasson; Pierfrancesco Pagella; Claudio Cantù ABSTRACT Upon WNT/β-catenin pathway activation, stabilized β-catenin travels to the nucleus where it associates with the TCF/LEF transcription factors, constitutively bound to genomic Wnt-responsive elements...

.... A strong translational selection of low-abundance transcripts involved in metabolic pathways and lysosomes was found throughout bovine embryonic development. Notably, genes involved in mitochondrial function were prioritized for translation. We found that translation largely reflected transcription...

...Laura J. Harrison; Daniel Bose ABSTRACT Enhancers confer precise spatiotemporal patterns of gene expression in response to developmental and environmental stimuli. Over the last decade, the transcription of enhancer RNAs (eRNAs) – nascent RNAs transcribed from active enhancers – has emerged...

...Cai-Li Bi; Qian Cheng; Ling-Yue Yan; Hong-Yan Wu; Qiang Wang; Ping Wang; Lin Cheng; Rui Wang; Lin Yang; Jian Li; Feng Tie; Hao Xie; Ming Fang ABSTRACT The evolutionarily conserved C-terminal binding protein (CtBP) has been well characterized as a transcriptional co-repressor. Herein, we report...

... ). Epigenetics and transcription regulation during eukaryotic diversification: the saga of TFIID . Genes Dev. 33 , 888 - 902 . 10.1101/gad.300475.117 Cao , J. , Spielmann , M. , Qiu , X. , Huang , X. , Ibrahim , D. M. , Hill , A. J. , Zhang , F. , Mundlos , S...

... alleles are transcriptionally active. The median fluorescence intensity of twi TSs along the DV axis was also uniform, indicating a similar rate of Pol II loading onto all twi loci throughout the mesodermal domain ( Fig. 2 D). The uniform activation of twi transcription is also corroborated...

... in transcription-dependent condensates . Science 361 , 412 - 415 . 10.1126/science.aar4199 Cisse , I. I. , Izeddin , I. , Causse , S. Z. , Boudarene , L. , Senecal , A. , Muresan , L. , Dugast-Darzacq , C. , Hajj , B. , Dahan , M. and Darzacq , X. ( 2013...

...Margherita Peron; Alberto Dinarello; Giacomo Meneghetti; Laura Martorano; Riccardo M. Betto; Nicola Facchinello; Annachiara Tesoriere; Natascia Tiso; Graziano Martello; Francesco Argenton ABSTRACT The STAT3 transcription factor, acting both in the nucleus and mitochondria, maintains embryonic stem...

... to understand how neural progenitor cells generate neuronal diversity in the developing central nervous system. However, not much is known about how temporal identity is encoded in progenitors to initiate the correct transcriptional code producing the appropriate cell types for a given developmental stage...

...Brett R. Lancaster; James D. McGhee ABSTRACT We define a quantitative relationship between the affinity with which the intestine-specific GATA factor ELT-2 binds to cis -acting regulatory motifs and the resulting transcription of asp-1 , a target gene representative of genes involved...

... silencing complex (RISC). The mechanism for growth inhibition does not, however, involve canonical roles as part of the RISC; rather, AGO1 controls cell and tissue growth by functioning as a direct transcriptional repressor of the master regulator of growth, Myc. AGO1 depletion in wing imaginal discs drives...

... transcriptional co-activators Yorkie, YAP and TAZ is far more dynamic than previously appreciated, and YAP and TAZ are also regulated by liquid-liquid phase separation. Here, we review our current understanding of Yorkie, YAP and TAZ regulation, with a focus on recent microscopy-based studies...

... ( Fig. 3 ), it appears that gene activation is likely to be the major mode of differential gene expression during Drosophila spermatogenesis. On the other hand, genes with stable levels of transcripts ( Fig. S7 ) could still be regulated post-transcriptionally, which is extensively used...

... with CHR2 ( Wang et al., 2018 ). CHR2 is an ATPase in the SWI2/SNF2 nucleosome remodeling complex, and affects miRNA expression not only through transcription, but also via an inhibitory role in remodeling primary(pri)-miRNAs to prevent their processing ( Wang et al., 2018 ). The mechanistic crossover...

... and cellular pathways that regulate prothoracic gland function are relatively well studied, the transcriptional regulators that orchestrate the activity of this tissue remain less characterized. Here, we show that lysine demethylase 5 (KDM5) is essential for prothoracic gland function. Indeed, restoring kdm5...

... Genome organization Phase separation Transcription The cell nucleus is a crowded environment. This is easily appreciated by considering that the almost 2 m long DNA polymer that comprises the human genome is packaged into a ∼6-10 µm diameter cell nucleus along with all the biological...

... patterns ( Fig. 1 , Fig. S1 and Table S1 ) supports our conclusions that these markers are associated with the pluripotent epiblast. It might be that changes in the transcription of these genes happens abruptly at ∼E8.25 and that there is a difficulty in staging the embryos. The transition from...

...Elena Sena; Nathalie Rocques; Caroline Borday; Harem Sabr Muhamad Amin; Karine Parain; David Sitbon; Albert Chesneau; Béatrice C. Durand ABSTRACT A hallmark of Wnt/β-Catenin signaling is the extreme diversity of its transcriptional response, which varies depending on the cell and developmental...

...Berta Terré; Michael Lewis; Gabriel Gil-Gómez; Zhiyuan Han; Hao Lu; Mònica Aguilera; Neus Prats; Sudipto Roy; Haotian Zhao; Travis H. Stracker ABSTRACT GEMC1 and MCIDAS are geminin family proteins that transcriptionally activate E2F4/5-target genes during multiciliogenesis, including Foxj 1...