... modifications. Distal-less-3 (DLX3) is a homeodomain transcription factor that is essential for tooth development. DLX3 is expressed in the dental mesenchymal cells starting from the cap stage ( Zhao et al., 2000 ). At postnatal day 3 (P3), DLX3 is highly expressed in preodontoblasts and odontoblasts ( Yang...

... specific gain- and loss-of-function approach, this study reveals that Wnt/β-catenin signaling is crucial in early development of the mouse molar. Tooth development Epithelial invagination Morphogenesis Wnt signaling Mouse National Institutes of Health http://dx.doi.org/10.13039...

... center Tooth development Teeth develop from oral epithelium and underlying mesenchyme through reciprocal interactions mediated by conserved signaling molecules ( Jussila and Thesleff, 2012 ). The shape of the tooth crown emerges during the morphogenesis of the epithelium via bud, cap and bell...

... unknown. In this study we used early mouse molar and incisor tooth germs that possess distinct tooth-forming capability after dissociation and reaggregation in vitro to investigate the mechanism that sustains odontogenic fate of dental mesenchyme during tooth development. We found that after dissociation...

... expression. Our in vivo and in vitro studies reveal a multistep transcriptional program involving the Pitx2:miR-200c/141:noggin regulatory pathway that is important in epithelial cell differentiation and tooth development. ChIP assays were performed as previously described using the ChIP Assay Kit...

... al., 2000 ; Zhao et al., 2000 ). This conclusion has been widely accepted and applied as an established principle for interpreting tooth developmental phenotypes, although the role of endogenous mesenchymal Bmp4 in tooth development has not been previously directly investigated. For example, a 24...

.... Ectodysplasin Edar Fgf20 Tooth development Evolution Mouse The regulation of organ form and complexity is a key question in biology. The development of complex structures requires specific sets of genes to be activated and/or inhibited in a correct temporal and spatial pattern. Gene...

...Youngwook Ahn; Brian W. Sanderson; Ophir D. Klein; Robb Krumlauf Mice carrying mutations in Wise ( Sostdc1 ) display defects in many aspects of tooth development, including tooth number, size and cusp pattern. To understand the basis of these defects, we have investigated the pathways modulated...

... is specific to loss of polaris activity in the mesenchyme since loss of Polaris in the epithelium has no detrimental affect on tooth development. To further confirm that upregulation of Shh activity is responsible for the ectopic tooth formation, we analysed mice mutant for Gas1 , a Shh protein antagonist...

...Martyn T. Cobourne; Isabelle Miletich; Paul T. Sharpe The signalling peptide encoded by the sonic hedgehog gene is restricted to localised thickenings of oral epithelium, which mark the first morphological evidence of tooth development, and is known to play a crucial role during the initiation...

... to develop but maxillary molars develop normally. In order to understand why maxillary molar tooth development can proceed in the absence of activin, we have explored the role of mediators of activin signalling in tooth development. Analysis of tooth development in activin receptor II and Smad2 mutants shows...

...Hélène R. Dassule; Paula Lewis; Marianna Bei; Richard Maas; Andrew P. McMahon ABSTRACT During mammalian tooth development, the oral ectoderm and mesenchyme coordinate their growth and differentiation to give rise to organs with precise shapes, sizes and functions. The initial ingrowth of the dental...

...Yanding Zhang; Zunyi Zhang; Xiang Zhao; Xueyan Yu; Yueping Hu; Benedicto Geronimo; Sigurd H. Fromm; YiPing Chen ABSTRACT The murine tooth development is governed by sequential and reciprocal epithelial-mesenchymal interactions. Multiple signaling molecules are expressed in the developing tooth germ...

..., and altered tooth development. The incisors of transgenic mice were fragile, chalky-white and, by scanning electron microscopy, their labial surface appeared granular. This phenotype was attributed to a defect in enamel formation during incisor development, resulting from structural and functional alterations...

...Marianna Bei; Richard Maas ABSTRACT During early tooth development, multiple signaling molecules are expressed in the dental lamina epithelium and induce the dental mesenchyme. One signal, BMP4, has been shown to induce morphologic changes in dental mesenchyme and mesenchymal gene expression via...

... 1998 © 1998 by Company of Biologists 1998 LIM homeodomain Lhx6 Lhx7 Fgf8 branchial arches tooth development epithelial-mesenchymal interactions medial ganglionic eminence Homeobox-containing genes constitute a class of transcriptional regulators that play critical roles...

... 1997 homeobox Dlx patterning tooth development neural crest mouse dentition odontogenic induction Tooth development is known to occur through a series of reciprocal epithelial-mesenchymal interactions. The initiation of tooth development involves an interaction between epithelium...

... exhibit defects in craniofacial development and a failure of tooth morphogenesis, with an arrest in molar tooth development at the E13.5 bud stage. Because of its potential for experimental manipulation, the murine molar tooth germ provides a powerful system for studying the role of Msx genes in inductive...

...Thomas Diekwisch; Sasson David; Pablo Bringas, Jr.; Valentino Santos; Harold C. Slavkin ABSTRACT During tooth development, enamel organ epithelial cells express a tissue-specific gene product (amelogenin) which presumably functions to control calcium hydroxyapatite crystal growth patterns during...

... outgrowths. Up until the cap stage of tooth development, Hox-8 is expressed predominantly in the epithelial tissues of the enamel organ, with an extremely limited expression domain in the dental papilla mesenchyme. By contrast, Hox-7 is expressed exclusively in the mesenchyme of the dental papilla...