... that, during the gastrula stage, TFAP2A acts as a pioneer factor in remodeling the epigenetic landscape required to activate components of the NPB induction program. Here, we show that chick Tfap2a has two highly conserved binding sites for miR-137, and both display a reciprocal expression pattern at the NPB...

... lineage assignment in the developing zebrafish pronephros by repressing Tfap2a activity. During renal ontogeny, expression of these factors colocalized with tfap2a in distal tubule precursors. kctd15a/b loss primed nephron cells to adopt distal fates by driving slc12a1 , kcnj1a.1 and stc1 expression...

... with discrete physiological identities. Here, from a forward genetic screen using zebrafish, we report the discovery that transcription factor AP-2 alpha ( tfap2a ) coordinates a gene regulatory network that activates the terminal differentiation program of distal segments in the pronephros. We found...

...Brigitte L. Arduini; Kevin M. Bosse; Paul D. Henion The neural crest generates multiple cell types during embryogenesis but the mechanisms regulating neural crest cell diversification are incompletely understood. Previous studies using mutant zebrafish indicated that foxd3 and tfap2a function early...

...Ting Luo; Yanhua Xu; Trevor L. Hoffman; Tailin Zhang; Thomas Schilling; Thomas D. Sargent Inca (induced in neural crest by AP2) is a novel protein discovered in a microarray screen for genes that are upregulated in Xenopus embryos by the transcriptional activator protein Tfap2a. It has...

... of the tfap2a gene that abolishes the last exon encoding the crucial protein dimerization and DNA-binding domains. Neural crest induction and specification are not hindered in mob m610 mutant embryos, as revealed by normal expression of early neural crest specific genes such as snail2 , foxd3 and sox10...