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1-3 of 3
Keywords: tetraploid
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Journal Articles
Journal:
Development
Development (1997) 124 (2): 279–287.
Published: 15 January 1997
... in vitro. Moreover, embryos derived solely from ES cells can be generated by aggregation with tetraploid morulae. Using Hnf-4 − /− ES cells we demonstrate that HNF-4 is a key regulator of tissue-speci?c gene expression in the VE, required for normal expression of secreted factors including alphafetoprotein...
Journal Articles
Journal:
Development
Development (1990) 110 (4): 1121–1132.
Published: 1 December 1990
...M. H. Kaufman; S. Webb Despite the fact that a variety of experimental techniques have been devised over the years to induce tetraploid mammalian embryonic development, success rates to date have been limited. Apart from the early study by Snow, who obtained development to term of a limited number...
Journal Articles
Journal:
Development
Development (1986) 96 (1): 211–228.
Published: 1 July 1986
... and cleaved into two equal blastomeres. After transfer to recipient does, 54·4% of these tetraploid embryos developed beyond implantation. Between day 11 and 20, ten live and morphologically fully normal embryos were recovered. Nine embryos were uniformly tetraploid and one recovered on day 18 was a diploid...