...- Arid2 Δ/Δ and littermate control testis. The results showed a similar phenotype to that observed in 2-month-old mice, with abundant lagging chromosomes and cell arrest at meiotic exit ( Fig. S5B ). The phenotype in testis development we observe agrees with a recent study, in which Arid2 is deleted...

... Disorders of sex development Sex determination Sry Testis development Transcriptional regulation Sex in mammals is usually determined by the presence or absence of Sry , a small, single-exon gene located in the male-specific region of the Y chromosome ( Gubbay et al., 1990 ; Sinclair et al...

... that Dax1 plays an early essential role in fetal testis development. We hypothesize that upregulation of Sox9 expression in precursor somatic cells, a process required for their differentiation as Sertoli cells, depends on the coordinated expression of Dax1 , Sry and another gene, Tda1 . Our conclusion...

...-mail: [email protected] ) * These authors contributed equally to this work 7 5 2004 ©2004. 2004 Pod1 Tcf21 Sf1 Gonadogenesis Testis development Sex reversal Leydig cell Mammalian sexual differentiation is a complex process that begins with the establishment of genetic...

... to the male gonadal environment is to generate a masculinising feedback loop to ensure male differentiation of the surrounding gonadal somatic cells. *Author for correspondence (e-mail: [email protected] ) 7 12 2001 © 2002. 2002 Primordial germ cells Testis development Sertoli...

... that in this marsupial species gonadal differentiation may be initiated in utero . © 1990 by Company of Biologists 1990 marsupials sex differentiation gonads testis development In eutherian mammals the sexual differentiation of the gonads occurs prenatally and the newborn are anatomi cally...

... , K. W. ( 1982 ). Sex reversal in the mouse (Mus musculus) is caused by a recurrent nonreciprocal crossover involving the X and an aberrant Y chromosome . Cell 28 , 205 – 216 . Singh , L. , Matsukuma , S. & Jones , K. ( 1987 ). Testis development...