... apoptosis protect organogenesis-stage limbs from insult with a teratogen. The absence of p53 may decrease DNA repair capacity and contribute to the accumulation of DNA damage in limb cells and their daughter cells; the failure of apoptosis to eliminate cells with DNA damage may result in increased cell...

... stagedependent craniofacial malformations comparable to those in corresponding human teratogen syndromes. Acute treatment regimens have allowed analysis of cell populations initially affected and subsequent dysmorphogenetic sequences as well as speculation relative to mechanisms of teratogenesis. In rodent...

... in humans. In reply, Dr Webster explained that the Accutane® levels in serum that are teratogenic in humans are well below the level achieved in the pregnant mouse. However, the whole embryo culture studies indicated that the 4-oxy-metabolite has roughly equal teratogenicity and that the combined human...