... the cell cycle of stem cells remain poorly understood. Here, we show that the Cdc25 homolog String (Stg) is a crucial regulator of germline stem cells (GSCs) and cyst stem cells (CySCs) in Drosophila testis. Through knockdown and overexpression experiments, we show that Stg is required for stem cell...

... 2007. 2007 Tissue elongation Planar cell polarity Pair rule string Mitosis Drosophila Fig. 3. Local tissue deformation in wild-type, eve and string embryos during the fast phase of germband extension. ( A , B )Individual nuclei (and their progeny) at the posterior...

... this process, we have identified and performed a functional analysis of genes whose transcription is responsive to the Notch pathway at this transition. These genes include the G2/M regulator Cdc25 phosphatase, String; a regulator of the APC ubiquitination complex Hec/Cdh Fzr and an inhibitor of the CyclinE...

...Dara A. Lehman; Briony Patterson; Laura A. Johnston; Tracy Balzer; Jessica S. Britton; Robert Saint; Bruce A. Edgar Mitosis in most Drosophila cells is triggered by brief bursts of transcription of string (stg) , a Cdc25-type phosphatase that activates the mitotic kinase, Cdk1 (Cdc2). To understand...

... of neuroblast NB 1-1. This first division of NB 1-1 (and of the other early neuroblasts as well) is temporally controlled by the transcriptional regulation of string expression, which we have manipulated experimentally. even-skipped expression still occurs if the first neuroblast division is delayed...

...; Artavanis-Tsakonas et al., 1995 ; Johnson and Tabin, 1995 ); however, few intrinsic factors have been characterized for both expression and function (see Rhyu et al., 1994 ; Guo and Kemphues, 1995 ). prospero Drosophila CNS numb string neuroblast GMC © 1995 by Company of Biologists...

... neuroblast sublin- eages. We show that these neuroblasts can be identified in embryos lacking both neuroblast cytokinesis and cell cycle progression ( string mutants) and in embryos lacking only neuroblast cytokinesis ( pebble mutants). We find that the unplugged and achaete genes are expressed normally...

...Bruce A. Edgar; Dara A. Lehman; Patrick H. O’Farrell ABSTRACT During postblastoderm embryogenesis in Drosophila , cell cycles progress in an invariant spatiotemporal pattern. Most of these cycles are differentially timed by bursts of transcription of string (cdc25) , a gene encoding a phosphatase...

...Catherine Courtot; Christian Fankhauser; Viesturs Simanis; Christian F. Lehner ABSTRACT We have identified a second cdc25 homolog in Drosophila . In contrast to string (the first homolog identified in Drosophila ) this second homolog, twine , does not function in the mitotic cell cycle...

... of the string gene (the Drosophila homologue of cdc25) , is not required for the endo cell cycle. The developmental regulation of the endo cell cycle is striking in that tissue-specific domains undergo polytene DNA replication in a dynamic pattern at defined times in embryogenesis. During subsequent rounds...