... is properly attributed. Summary: Initiation and termination of female germline stem cell differentiation requires the appearance and clearance of the same regulator, Bag of marbles. Germline RNA stability Post-transcriptional regulation Stem cells Drosophila Wellcome Trust http...

... experiments demonstrate that adult spheroid-generating cells belong to a hitherto undescribed developmental lineage, independent of Lgr5+ve CBCs, and are involved in regeneration of the epithelium following CBC ablation. ‡ Present address: Core Unit pluripotent Stem Cells and Organoids (CUSCO), Berlin...

...Gabriela S. Vida; Elizabeth Botto; Stephen DiNardo ABSTRACT Stem cells are essential to repair and regenerate tissues, and often reside in a niche that controls their behavior. Here, we use the Drosophila testis niche, a paradigm for niche–stem cell interactions, to address the cell biological...

...Rodrigo García-Tejera; Jing-Yi Tian; Marc Amoyel; Ramon Grima; Linus J. Schumacher ABSTRACT To maintain and regenerate adult tissues after injury, division and differentiation of tissue-resident stem cells must be precisely regulated. It remains elusive which regulatory strategies prevent...

... to altered villus architecture and impaired junction integrity without affecting the segregation of apical and basolateral membrane domains. Further, RAB6 depletion slowed down cell migration and adversely affected both cell proliferation and stem cell maintenance. Notably, the absence of RAB6 resulted...

... is required to avert this disaster. In this Spotlight, we draw together insights and proposals discussed at a recent workshop hosted by Revive & Restore, which gathered experts to discuss how stem cell technologies can support traditional conservation techniques and help protect animal biodiversity. We...

.... O. ( 2019 ). Characterization of a novel decellularized bone marrow scaffold as an inductive environment for hematopoietic stem cells . Biomater. Sci. 7 , 1516 - 1528 . 10.1039/c8bm01503a Bowers , M. , Zhang , B. , Ho , Y. , Agarwal , P. , Chen , C.-C...

...-term self-renewing (e.g. stem cell) population. Newly developed generalized birth-death modeling of long-term lineage tracing data shows that both TA progenitors and stem cells display neutral competition, but only the stem cells display neutral drift. The quantitative evolution of a nascent TA cell...

... to the balance between stem cell replenishment and cell recruitment into new organs. In angiosperms, the transcription factor WUSCHEL (WUS) promotes stem cell proliferation in the central zone of the SAM. WUS forms a negative feedback loop with a signaling pathway activated by CLAVATA3 (CLV3). In the periphery...

... took place in Vienna in March 2024, covering topics such as early embryogenesis, nervous system development and disease, regeneration and the latest technologies. Early embryogenesis Organoids Single cell technologies Stem cells Deutsche Forschungsgemeinschaft http://dx.doi.org...

...Tiffany V. Roach; Kari F. Lenhart ABSTRACT Germline maintenance relies on adult stem cells to continually replenish lost gametes over a lifetime and respond to external cues altering the demands on the tissue. Mating worsens germline homeostasis over time, yet a negative impact on stem cell...

... development, but the molecular details of how dIs arise as distinct populations of neurons remain incomplete. We have developed a resource to investigate dI fate specification by combining a single-cell RNA-Seq atlas of mouse embryonic stem cell-derived dIs with pseudotime analyses. To validate this in silico...

...Marco Possenti; Giovanna Sessa; Altea Alfè; Luana Turchi; Valentino Ruzza; Massimiliano Sassi; Giorgio Morelli; Ida Ruberti ABSTRACT In multicellular organisms, specialized tissues are generated by specific populations of stem cells through cycles of asymmetric cell divisions, where one daughter...

...Daniel Doro; Annie Liu; Jia Shang Lau; Arun Kumar Rajendran; Christopher Healy; Marko Krstic; Agamemnon E. Grigoriadis; Sachiko Iseki; Karen J. Liu ABSTRACT The cranial sutures are proposed to be a stem cell niche, harbouring skeletal stem cells that are directly involved in development...

... Summary: This Review discusses the chromatin modifications associated with the mammalian female inactive X chromosome and their relevance to gene silencing and potential for therapeutic modulation. X inactivation Epigenetics Female Gene silencing Stem cells National Health and Medical...

... of Biologists Ltd 2023 Summary: This Review provides an overview of the remarkable roles that metabolism and metabolic switches play during development, differentiation and regeneration. Metabolic switch Embryonic development Postnatal development Regeneration Reprogramming Stem cells...

... that drive tissue repair and, in some cases, the development of specific cell types. Although macrophages display directed orchestration of stem cell activities, bidirectional cellular crosstalk mechanisms allow stem cells to regulate macrophage behaviour within their niche, thus increasing the complexity...

.... The stoichiometry of this modification is tightly controlled throughout all stages of development, with both hypo/hyper O-GlcNAcylation resulting in broad defects. In this Primer, we discuss the role of O-GlcNAcylation in developmental processes from stem cell maintenance and differentiation to cell and tissue...

... stem cell lineages also exhibit clear differences in Ribi and protein synthesis during different stages of differentiation. For example, hematopoietic stem cells exhibit low levels of protein synthesis relative to their differentiating progeny ( Signer et al., 2014 , 2016 ; Jarzebowski et al., 2018...

... talks revealed novel insights into stem cell dynamics and the role of mechanical forces during epithelial homeostasis and repair. Pantelis Rompolas (Philadelphia, USA) examined the heterogeneity and functional organisation of corneal stem cells in the mouse limbus of the eye. He showed that actively...