... of the mitotic spindle in vitro in human cells and in vivo in Xenopus . Investigation of CHD2 provides evidence that mutations present in individuals with ASD cause a range of microtubule-related phenotypes, including disrupted localization of the protein at mitotic spindles, cell cycle stalling, DNA damage...

... mitoses are severely affected by mutations that result in a substantial decrease in the ratio of αTUB67C/ αTUB84B+ αTUB84D. A large increase in this ratio, achieved by increasing the gene dosage of Tub67C , has little or no effect on meiosis, but severely disrupts mitotic spindle function. Thus, both...