... of a dorsally located organizer. This interplay generates a zygotic Bmp activity gradient that defines distinct positional values along the DV axis. The maternal processes that control expression of the zygotic genes implicated in DV patterning are largely unknown. spiel-ohne-grenzen ( spg/pou2...

... roles in specifying distinct rhombomeres and in controlling segmental identity by directly regulating rhombomere-specific expression of Hox genes. We show that spiel ohne grenzen ( spg ) zebrafish mutants develop rhombomeric territories that are abnormal in both size and shape. Rhombomere boundaries...

... expression domains positions the MHB. How the positional information is translated into activation of Pax2 , Wnt1 and Fgf8 expression during MHB establishment remains unclear. In zebrafish spiel ohne grenzen ( spg ) mutants, the MHB is not established, neither isthmus nor cerebellum form, the midbrain...