... by chromosomal abnormalities, mutations and epigenetic defects. Epigenetic modifiers pre-program hundreds of spermatogenic genes in spermatogonial stem cells (SSCs) for expression later in spermatids, but it remains mostly unclear whether and how those genes are involved in fertility. Here, we report...

... signaling molecules, transcription factors and epigenetic modifiers. Spermatogenesis Meiosis Spermiogenesis Primordial germ cell Gonocyte Spermatogonium Spermatogonial stem cell Spermatocyte Spermatid Chinese STI 2030-Major Projects 2023ZD040750305 National Natural...

... was recently shown to require mitochondrial fusion and fission. Mitophagy, the autophagic degradation of mitochondria, is another mechanism for controlling mitochondrial number and physiology, but its role during spermatogenesis is largely unknown. During post-meiotic spermatid development, restructuring...

... an essential role in spermatid morphogenesis. Loss of Tsga8 in mice leads to male infertility associated with abnormal chromosomal distribution in round spermatids, malformation of elongating spermatid heads and spermiation failure. Tsga8 depletion leads to dysregulation of thousands of genes, including the X...

...Carine Barreau; Elizabeth Benson; Elin Gudmannsdottir; Fay Newton; Helen White-Cooper Post-meiotic transcription was accepted to be essentially absent from Drosophila spermatogenesis. We identify 24 Drosophila genes whose mRNAs are most abundant in elongating spermatids. By single-cyst quantitative...

... of meiosis I in males and for onset of spermatid differentiation. In males mutant for any one of these meiotic arrest genes, mature primary spermatocytes with partially condensed chromosomes accumulate and post-meiotic cells are lacking. The arrest in cell-cycle progression occurs prior to degradation...

...Yasuyuki Kimura; R. Yanagimachi ABSTRACT Genomic imprinting occurs in both male and female gametes during gametogenesis, but the exact time when imprinting begins and ends is unknown. In the present study we injected nuclei of testicular spermatozoa and round spermatids into mature mouse oocytes...