...Cristina M. Ostalé; Diego Pulido; Patricia Vega-Cuesta; Ana López-Varea; Jose F. de Celis ABSTRACT The Spalt transcriptional regulators participate in a variety of cell fate specification processes during development, regulating transcription through interactions with DNA AT-rich regions. Spalt...

... species with more complex venation Bicyclus anynana and Pieris canidia . We also test the function of some of these genes in B. anynana . We identify both conserved as well as new domains of decapentaplegic , engrailed , invected , spalt , optix , wingless , armadillo , blistered and rhomboid gene...

... expression in the presumptive L2 vein of the wing imaginal disc. We find that knirps is regulated by four Decapentaplegic target genes encoding the transcription factors aristaless , spalt major , spalt-related and optix . The expression of optix is activated by Dpp and repressed by the Spalt proteins...

... combinatorial transcription factor input, feedback and redundancy, are coordinated to drive dve expression in the Drosophila eye. Defective proventriculus Shadow enhancer Dark shadow enhancer Rhodopsin Drosophila retina Photoreceptor Spineless Orthodenticle Spalt Genes are expressed...

.... We show that changes in the domains of spalt and cut expression in the embryo are associated with the acquisition of each structure. Moreover, we show that these two genetic modifications are connected both functionally and genetically, thus providing an evolutionary scenario by which a genetic event...

...-specific choice between the two seamless tube types depends on the tracheal branch identity gene spalt major , which is sufficient to inhibit TC specification. Thus, a single repressor, Aop, integrates two different signals to couple tip cell fate selection with branch identity. The switch from a branching...

... differences among the Ubx isoforms can be compensated for by increasing the expression levels of the less efficient form. The analysis of the DNA-binding profiles of Ubx isoforms to a natural Ubx target, spalt , shows no major differences in isoform DNA-binding activities, suggesting that alternative splicing...

... lines. These studies indicate that Sall1 -dependent signals from the metanephric mesenchyme are required to modulate ureteric bud tip Wnt patterning in order to initiate branching. Sall1 Spalt Ureter Wnt9b Kidney development Ureteric bud Metanephric mesenchyme β-catenin Wnt Tip fate Mouse...

...Masayo Sakaki-Yumoto; Chiyoko Kobayashi; Akira Sato; Sayoko Fujimura; Yuko Matsumoto; Minoru Takasato; Tatsuhiko Kodama; Hiroyuki Aburatani; Makoto Asashima; Nobuaki Yoshida; Ryuichi Nishinakamura Mutations in SALL4 , the human homolog of the Drosophila homeotic gene spalt ( sal ), cause...

.... 2006 sall4 sall1 spalt tbx5 Pectoral fins Zebrafish Okihiro syndrome Holt-Oram syndrome Mutations in the gene SALL4 result in Okihiro syndrome [OS, also called Duane radial ray syndrome (DRRS), OMIM number 607323]( Al-Baradie et al., 2002 ; Kohlhase et al...

... specifies R3 and induces Delta , which activates Notch in the neighboring cell, specifying it as R4. Here, we show that the spalt zinc-finger transcription factors( spalt major and spalt-related ) are part of the molecular mechanisms regulating R3/R4 specification and planar cell polarity establishment...

...Anne S. Toker; Yingqi Teng; Henrique B. Ferreira; Scott W. Emmons; Martin Chalfie Members of the spalt (sal) gene family encode zinc-finger proteins that are putative tumor suppressors and regulate anteroposterior (AP) patterning,cellular identity, and, possibly, cell cycle progression...

...Rafael Cantera; Karin Lüer; Tor Erik Rusten; Rosa Barrio; Fotis C. Kafatos; Gerhard M. Technau The gene spalt is expressed in the embryonic central nervous system of Drosophila melanogaster but its function in this tissue is still unknown. To investigate this question, we used a combination...

... fate. Here we test which antenna patterning genes are targets of Homothorax, Distal-less and/or Spineless. We report that the antennal expression of dachshund , atonal , spalt , and cut requires Homothorax and/or Distal-less, but not Spineless. We conclude that Distal-less and Homothorax specify...

...-specifying gene, homothorax , in conjunction with dachshund and spalt , and there is much less overlap between the bric a brac and the dachshund domains. Thus tissue-specific expression of other patterning genes that differentially repress bric a brac accounts for antenna-leg differences in bric a brac...

... genetic studies have revealed a developmental system for patterning appendages and identified several genes required for limb development. Among these are: extradenticle ( exd ) , homothorax ( hth ) , dachshund ( dac ), Distal-less ( Dll ) and spalt ( sal ). These limb genes have not been well studied...

...Tor Erik Rusten; Rafael Cantera; Joachim Urban; Gerhard Technau; Fotis C. Kafatos; Rosa Barrio Genes of the spalt family encode nuclear zinc finger proteins. In Drosophila melanogaster , they are necessary for the establishment of head/trunk identity, correct tracheal migration and patterning...

... functions, including specifying the dorsal trunk through activation of Spalt expression and inducing differentiation of fusion cells in all fusion branches. Moreover, we show that Wingless signaling regulates Notch signaling by stimulating Delta expression at the tip of primary branches. These activities...

... identified antennal selector gene, to induce antennal differentiation. While mutations in either Distal-less or homothorax cause antenna-to-leg transformations, neither gene is required for the others expression, and both genes are required for antennal expression of spalt . Coexpression of Distal-less...

...José F. de Celis; Rosa Barrio; Fotis C. Kafatos ABSTRACT The nuclear proteins Spalt and Spalt-related belong to a conserved family of transcriptional regulators characterised by the presence of double zinc-finger domains. In the wing, they are regulated by the secreted protein Decapentaplegic...