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Keywords: sox2
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Journal Articles
Journal: Development
Development (2022) 149 (14): dev200547.
Published: 21 July 2022
...Daniel W. Hagey; Maria Bergsland; Jonas Muhr ABSTRACT The transcription factor SOX2 is a vital regulator of stem cell activity in various developing and adult tissues. Mounting evidence has demonstrated the importance of SOX2 in regulating the induction and maintenance of stemness as well...
Journal Articles
Journal: Development
Development (2020) 147 (14): dev187922.
Published: 26 July 2020
... development in the mouse retina. We identified seven Otx2 cis -regulatory modules (CRMs), among which the O5, O7 and O9 CRMs mark three distinct cellular contexts of Otx2 expression. We discovered that Otx2, Crx and Sox2, which are well-known TFs regulating retinal development, bind to and activate the O5, O7...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (14): dev187922.
Published: 26 July 2020
... development in the mouse retina. We identified seven Otx2 cis -regulatory modules (CRMs), among which the O5, O7 and O9 CRMs mark three distinct cellular contexts of Otx2 expression. We discovered that Otx2, Crx and Sox2, which are well-known TFs regulating retinal development, bind to and activate the O5, O7...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev186023.
Published: 4 June 2020
... epithelial invagination, and decreases progenitor cell proliferation and dental epithelium cell differentiation. Developmentally, Pitx2 regulates formation of the Sox2 + labial cervical loop (LaCL) stem cell niche in concert with two signaling centers: the initiation knot and enamel knot. The loss of Pitx2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (11): dev186023.
Published: 4 June 2020
... epithelial invagination, and decreases progenitor cell proliferation and dental epithelium cell differentiation. Developmentally, Pitx2 regulates formation of the Sox2 + labial cervical loop (LaCL) stem cell niche in concert with two signaling centers: the initiation knot and enamel knot. The loss of Pitx2...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev180018.
Published: 22 January 2020
... in specific behavioral defects. To broaden evidence for Ars2 as a chromatin regulator in neural development, we generated Ars2 ChIP-seq data. Notably, Ars2 preferentially occupies DNA enhancers in NSCs, where it colocalizes broadly with NSC regulator SOX2. Ars2 association with chromatin is markedly reduced...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2020) 147 (2): dev180018.
Published: 22 January 2020
... in specific behavioral defects. To broaden evidence for Ars2 as a chromatin regulator in neural development, we generated Ars2 ChIP-seq data. Notably, Ars2 preferentially occupies DNA enhancers in NSCs, where it colocalizes broadly with NSC regulator SOX2. Ars2 association with chromatin is markedly reduced...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (13): dev170522.
Published: 21 June 2019
...Aleta R. Steevens; Jenna C. Glatzer; Courtney C. Kellogg; Walter C. Low; Peter A. Santi; Amy E. Kiernan ABSTRACT The transcription factor sex determining region Y-box 2 (SOX2) is required for the formation of hair cells and supporting cells in the inner ear and is a widely used sensory marker...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev171363.
Published: 8 February 2019
... side of the first tooth from the successional dental lamina. This lamina expresses the stem/progenitor marker Sox2 and has activated Wnt/β-catenin signalling at its tip. Although the mouse does not replace its teeth, a transient rudimentary successional dental lamina (RSDL) still forms during...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2019) 146 (3): dev171363.
Published: 8 February 2019
... side of the first tooth from the successional dental lamina. This lamina expresses the stem/progenitor marker Sox2 and has activated Wnt/β-catenin signalling at its tip. Although the mouse does not replace its teeth, a transient rudimentary successional dental lamina (RSDL) still forms during...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal: Development
Development (2018) 145 (1): dev154393.
Published: 11 January 2018
... of the auditory bulla and around the ear drum. Sox2 was widely expressed in the endodermally derived ciliated pseudostratified epithelium of the hypotympanum. This part of the middle ear showed high levels of Wnt activity, as indicated by the expression of Axin2, a readout of Wnt signalling. Keratin 5 showed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev154393.
Published: 11 January 2018
... of the auditory bulla and around the ear drum. Sox2 was widely expressed in the endodermally derived ciliated pseudostratified epithelium of the hypotympanum. This part of the middle ear showed high levels of Wnt activity, as indicated by the expression of Axin2, a readout of Wnt signalling. Keratin 5 showed...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev155929.
Published: 8 January 2018
...Maria Sanz-Navarro; Kerstin Seidel; Zhao Sun; Ludivine Bertonnier-Brouty; Brad A. Amendt; Ophir D. Klein; Frederic Michon ABSTRACT In mice, the incisors grow throughout the animal's life, and this continuous renewal is driven by dental epithelial and mesenchymal stem cells. Sox2 is a principal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2018) 145 (1): dev155929.
Published: 8 January 2018
...Maria Sanz-Navarro; Kerstin Seidel; Zhao Sun; Ludivine Bertonnier-Brouty; Brad A. Amendt; Ophir D. Klein; Frederic Michon ABSTRACT In mice, the incisors grow throughout the animal's life, and this continuous renewal is driven by dental epithelial and mesenchymal stem cells. Sox2 is a principal...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Journal Articles