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Keywords: slug
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Journal Articles
Journal: Development
Development (2011) 138 (15): 3135–3145.
Published: 01 August 2011
... gastrulation. The transcription factors Snail2 (Slug), Snail1 and Twist1 are expressed in this region. It is known that Snail2 and Twist1 are required for both mesoderm formation and neural crest induction. Using targeted blastomere injection, morpholino-based loss of function and explant studies, we show...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2009) 136 (5): 771–779.
Published: 01 March 2009
... the importance of considering the order of exposure to signals during an inductive event. * Author for correspondence (e-mail: r.mayor@ucl.ac.uk ) 30 12 2008 © 2009. 2009 Neural crest induction Mesoderm Wnt BMP Slug Sox2 The neural crest (NC) is a cell population...
Journal Articles
Journal: Development
Development (2008) 135 (7): 1283–1293.
Published: 01 April 2008
... crest (NC) at neurula stages, and in NC derivatives and other dorsal structures during tailbud stages. A prominent consequence of the morpholino-induced inhibition of Lrig3 expression was impaired NC formation, as revealed by the suppression of marker genes, including Slug , Sox9 and Foxd3. In the NC...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (23): 4255–4263.
Published: 01 December 2007
.... * Author for correspondence (e-mail: niehrs@dkfz-heidelberg.de ) 4 9 2007 © 2007. 2007 Dkk Kremen LRP6 Mesd Slug Sox10 Wnt Xenopus The canonical Wnt/β-catenin signaling cascade is an evolutionarily conserved and ancient pathway playing major roles during animal...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2007) 134 (9): 1789–1797.
Published: 01 May 2007
... encodes transcriptional repressors that play essential roles in the growth and patterning of vertebrate embryos. Here we report the functions of Snail ( Snai1 ) and Slug ( Snai2 ) genes during palate development in mice. Snai2 -/- mice exhibit cleft palate, which is completely penetrant on a Snai1...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (17): 3359–3370.
Published: 01 September 2006
...Ann E. Vernon; Carole LaBonne The neural crest is a population of stem-cell-like precursors found only in vertebrates. Slug, a member of the Snail family of zincfinger transcriptional repressors, is a critical regulator of neural crest development and has also been implicated in the acquisition...
Includes: Supplementary data
Journal Articles
Journal: Development
Development (2006) 133 (7): 1323–1333.
Published: 01 April 2006
...Daisuke Sakai; Takashi Suzuki; Noriko Osumi; Yoshio Wakamatsu In neural crest formation, transcription factors, such as group E Sox and Snail1 / Snail2 ( Slug ) regulate subsequent epithelial-mesenchymal transition (EMT) and migration. In particular, Sox9 has a strong effect on neural crest...
Journal Articles
Journal: Development
Development (2005) 132 (8): 1831–1841.
Published: 15 April 2005
... to this work 2 2 2005 ©2005. 2005 Xenopus Neural crest Id3 Myc Wnt Slug Stem cell Neural crest precursor cells arise at the lateral edges of the neural plate as early as mid-gastrulation (Knecht and Bronner-Fraser, 2001). Around the time of neural tube closure, these cells...
Journal Articles
Journal: Development
Development (2003) 130 (26): 6441–6452.
Published: 29 December 2003
... conditional gain- and loss-of-function experiments using different msx1 constructs fused to a glucocorticoid receptor element to avoid an early effect of this factor. We show that msx1 expression is able to induce all other early neural crest markers tested ( snail,slug, foxd3 ) at the time of neural crest...
Journal Articles
Journal: Development
Development (2003) 130 (3): 483–494.
Published: 01 February 2003
... of the Snail family, Snail and Slug , have both been implicated in this cascade. In chick and Xenopus , loss- and gain-of-function experiments have provided evidence that Slug plays a key role in neural crest development. However, in contrast to the chick, Snail rather than Slug is expressed...
Journal Articles
Journal: Development
Development (2003) 130 (2): 331–342.
Published: 15 January 2003
... for correspondence (e-mail: mmercola@burnham.org ) 10 10 2002 © 2003. 2003 Dlx Neural crest Neural induction Xenopus hairy2a slug snail msx The juxtaposition of presumptive neural plate and epidermis forms a signaling center responsible for the stereotypic pattern...
Journal Articles
Journal: Development
Development (2002) 129 (7): 1583–1593.
Published: 01 April 2002
...Marta G. del Barrio; M. Angela Nieto The Snail gene family of transcription factors plays crucial roles in different morphogenetic processes during the development of vertebrate and invertebrate embryos. In previous studies of function interference for one of the family members, Slug , we showed...
Journal Articles
Journal: Development
Development (2002) 129 (4): 863–873.
Published: 15 February 2002
... in the epidermis additionally inhibits neural crest formation in this tissue, so that neural crest generation by BMP4 is restricted to the junction. *Author for correspondence (e-mail: wakasama@mail.cc.tohoku.ac.jp ) 23 11 2001 © 2002. 2002 Neural crest Notch signaling Slug BMP4...
Journal Articles
Journal: Development
Development (2001) 128 (19): 3655–3663.
Published: 01 October 2001
... in a vertebrate Wnt signaling pathway. Curr. Biol . 6 , 1302 -1306. *Author for correspondence (e-mail: pklein@hhmi.upenn.edu ) 6 7 2001 © 2001. 2001 Xenopus Xwnt Frizzled Neural crest Xfz3 Slug Vertebrate embryo Melanocyte More than 20 Wnt genes have been...
Journal Articles
Journal: Development
Development (2001) 128 (13): 2525–2536.
Published: 01 July 2001
... region starts at the late gastrula stage in a manner similar to that of Slug , and overlaps with that of Zic-r1 . When overexpressed in the embryo and in ectodermal explants, FoxD3 induces expression of neural crest markers. Attenuation of FoxD3-related signaling by a dominant-negative FoxD3 construct...