...Hiroyuki Yamaguchi; Matthew D. Meyer; Li He; Lakmini Senavirathna; Sheng Pan; Yoshihiro Komatsu ABSTRACT Intramembranous ossification, which consists of direct conversion of mesenchymal cells to osteoblasts, is a characteristic process in skull development. One crucial role of these osteoblasts...

..., a special feature of the lepidotrichia bone of the fish fin, or a process found more generally in fish bone. Here, we show that dedifferentiation of mature osteoblasts is not restricted to fin regeneration after amputation, but also occurs during repair of zebrafish fin fractures and skull injuries. In both...

...L. Henry Goodnough; Andrew T. Chang; Charles Treloar; Jing Yang; Peter C. Scacheri; Radhika P. Atit The bones of the mammalian skull vault form through intramembranous ossification. Skull bones ossify directly, in a process regulated by β-catenin, instead of passing through a cartilage intermediate...

... by malformations of the skull, limbs and viscera. Two-thirds of affected individuals have a S252W mutation in fibroblast growth factor receptor 2(FGFR2). To study the pathogenesis of this condition, we generated a knock-in mouse model with this mutation. The Fgfr2 +/S252W mutant mice have abnormalities...

...Sanjukta Sarkar; Anita Petiot; Andrew Copp; Patrizia Ferretti; Peter Thorogood The cranial neural crest gives rise to most of the skeletal tissues of the skull. Matrix-mediated tissue interactions have been implicated in the skeletogenic differentiation of crest cells, but little is known...

...S. Iseki; A. O. M. Wilkie; G. M. Morriss-Kay Fibroblast growth factor receptors (FGFRs) play major roles in skeletogenesis, and activating mutations of the human FGFR1, FGFR2 and FGFR3 genes cause premature fusion of the skull bones (craniosynostosis). We have investigated the patterns...

...S. Iseki; A. O. M. Wilkie; J. K. Heath; T. Ishimaru; K. Eto; G. M. Morriss-Kay ABSTRACT Mutations in the human fibroblast growth factor receptor type 2 ( FGFR2 ) gene cause craniosynostosis, particularly affecting the coronal suture. We show here that, in the fetal mouse skull vault, Fgfr2...

... of the frontonasal mass and of the second and third pharyngeal arches. RAR double mutants also exhibit supernumerary cranial skeletal elements that are present in the ancestral reptilian skull. The role of retinoic acid (RA) and of the RARs in the ontogenesis of the affected structures, particularly of those...

... epigenesis neural crest somitomeres skull tooth development Noden’s paper provided an overview of the current evidence documenting the four sources of mesoderm in the head of the developing chick: prechordal plate, lateral plate and paraxial mesoderm, both somitomeres and occipital somites...

...Peter Thorogood ABSTRACT The initial form of the embryonic bony skull is determined in two ways; cranially, by the relative growth of the developing brain, and facially, by the chondrocranium. Both are essentially acting as structural templates around which the bony components of the skull...