... been experimentally observed in vivo . Here, we identify such a TA population using clonal analysis of Aspm-CreER genetic cell-marking in mice, which uncovers contribution to both homeostasis and injury repair of adult skin. This TA population is more frequently dividing than a Dlx1-CreER-marked long...

... defense. In murine tail skin, interfollicular epidermis patterns into pigmented ‘scale’ and hypopigmented ‘interscale’ epidermis. Why and how mature melanocytes accumulate in scale epidermis is unresolved. Here, we delineate a cellular hierarchy among epidermal cell types that determines skin patterning...

...René Reitermaier; Tanya Ayub; Julia Staller; Philip Kienzl; Nikolaus Fortelny; Pablo Augusto Vieyra-Garcia; Christof Worda; Christian Fiala; Clement Staud; Wolfgang Eppel; Anke Scharrer; Thomas Krausgruber; Adelheid Elbe-Bürger ABSTRACT The adult human skin contains a vast number of T cells...

... of PNPLA1 or CERS3 in humans results in barrier disruption and skin defects ( Ting et al., 2005 ; de la Garza et al., 2013 ; Eckl et al., 2013 ; Grond et al., 2017 ). Consistent with these findings, Urwyler-Rösselet and colleagues showed that epidermal differentiation defects seen in RIPK4-null...

... to the skin surface. Here, we demonstrate that the randomly oriented hair phenotype observed in frizzled 6 ( Fzd6 ) mutants results from a partial loss of the polarity, due to the functional redundancy of another closely related frizzled gene, Fzd3 . Double knockout of Fzd3 and Fzd6 globally, or only...

... mechanisms of cell fate regulation through niche-derived cues, with a particular focus on epithelial stem cells of the mammalian skin, intestine and lung. We discuss a spectrum of niche-derived biochemical, mechanical and architectural inputs that define stem cell states during morphogenesis, homeostasis...

... tracing and targeted gene disruption and gain of function identify a novel source of lymphatic endothelial progenitors that contribute to the formation of lymphatic vasculature in mouse skin. Lymphatic endothelial cells Skin Lymphangiogenesis PROX1 Lineage tracing Progenitor cell Mouse...

...Blair A. Jenkins; Ellen A. Lumpkin The sensation of touch is mediated by mechanosensory neurons that are embedded in skin and relay signals from the periphery to the central nervous system. During embryogenesis, axons elongate from these neurons to make contact with the developing skin...

... cellular processes that take place both within the epidermis and in other participating tissues. Re-epithelialization of partial- or full-thickness skin wounds of adult zebrafish, however, is extremely rapid and largely independent of the other processes of wound healing. Live imaging after treatment...

[email protected] ) Competing interests The authors declare no competing or financial interests. 11 7 2014 1 5 2015 © 2015. Published by The Company of Biologists Ltd 2015 Summary: In mouse skin, depletion of the ciliary IFT27 protein impairs SMO and GLI2 trafficking and GLI...

...Carolina N. Perdigoto; Evan S. Bardot; Victor J. Valdes; Francis J. Santoriello; Elena Ezhkova Merkel cell–neurite complexes are located in touch-sensitive areas of the mammalian skin and are involved in recognition of the texture and shape of objects. Merkel cells are essential for these tactile...

...) hair follicles and their associated structures in the skin; (2) stereociliary bundles on the apical faces of inner ear sensory hair cells; and (3) motile cilia in the trachea and on the walls of the cerebral ventricles that direct the vectorial movement of mucus and cerebrospinal fluid, respectively...

... ontogeny has not been determined yet. These elusive precursors are believed to migrate into the embryonic skin and to express primitive surface markers, including CD36, but not typical LC markers such as CD1a, CD1c and CD207. The aim of this study was to further characterize the phenotype of LC precursors...

... follicle stem cells are maintained in a quiescent state until they receive signals to proliferate. We found that the forkhead transcription factor Foxp1 is crucial for maintaining the quiescence of hair follicle stem cells. Loss of Foxp1 in skin epithelial cells leads to precocious stem cell activation...

... Skin Mouse The hair follicle (HF) has emerged as an informative system in which to study adult stem cell biology because it is characterized by predictable and precisely choreographed phases of growth (anagen), regression (catagen) and rest (telogen; Fig. 1A ). Hair growth is, in part...

...Barbara A. Schmidt; Valerie Horsley Acute wound healing in the skin involves the communication of multiple cell types to coordinate keratinocyte and fibroblast proliferation and migration for epidermal and dermal repair. Many studies have focused on the interplay between hematopoietic cells...

...Zhu Juan Li; Erica Nieuwenhuis; Weilun Nien; Xiaoyun Zhang; Jennifer Zhang; Vijitha Puviindran; Brandon J. Wainwright; Peter C. W. Kim; Chi-chung Hui Abnormal activation of Hedgehog (Hh) signaling leads to basal cell carcinoma (BCC) of the skin, the most common human cancer. Gli2, the major...

... defense against micro-organisms and in the pathophysiology of several inflammatory skin diseases. To understand the role of TLRs in the acquisition of immunological competence, we conducted a comprehensive study to evaluate TLR expression and function in the developing human skin before and after birth...

...; however, little is known of their functions in postnatal hair growth. We compared the effects of deleting the essential miRNA biogenesis enzymes Drosha and Dicer in mouse skin epithelial cells at successive postnatal time points. Deletion of either Drosha or Dicer during an established growth phase...

...Seung-Hyun Woo; Yoshichika Baba; Alexa M. Franco; Ellen A. Lumpkin; David M. Owens The piloneural collar in mammalian hairy skin comprises an intricate pattern of circumferential and longitudinal sensory afferents that innervate primary and secondary pelage hairs. The longitudinal afferents tightly...