...Simone Gabner; Peter Böck; Dieter Fink; Martin Glösmann; Stephan Handschuh ABSTRACT For decades, clearing and staining with Alcian Blue and Alizarin Red has been the gold standard to image vertebrate skeletal development. Here, we present an alternate approach to visualise bone and cartilage based...

... belongs to the mitogen-activated protein kinase (MAPK) family. Following its phosphorylation by Mek5, Erk5 modulates several signaling pathways in a number of cell types. In this study, we demonstrated that Erk5 inactivation in mesenchymal cells causes abnormalities in skeletal development by inducing...

...Kannan Karuppaiah; Kai Yu; Joohyun Lim; Jianquan Chen; Craig Smith; Fanxin Long; David M. Ornitz ABSTRACT Fibroblast growth factor (FGF) signaling is important for skeletal development; however, cell-specific functions, redundancy and feedback mechanisms regulating bone growth are poorly understood...

... receptors to directly influence cell behavior. To explore functions of HA in limb skeletal development, we conditionally inactivated the gene for HA synthase 2, Has2 , in limb bud mesoderm using mice that harbor a floxed allele of Has2 and mice carrying a limb mesoderm-specific Prx1-Cre transgene...

... for correspondence (e-mail: [email protected] ) 28 10 1997 08 12 1997 © 1998 by Company of Biologists 1998 δEF1 Gene targeting Skeletal development DNA binding protein Mouse Skeletons of vertebrates develop from three distinct lineages ( Erlebacher et al., 1995...

.... Two vertebrate hedgehog proteins, Sonic hedgehog and Indian hedgehog, have been implicated in skeletal development. During somite differentiation and limb development, Sonic hedgehog functions as an inductive signal from the notochord, floor plate and zone of polarizing activity. Later...