... compared with controls but also compared with hearts from other heterotaxic embryos. In most cases, LR cell lineage defects were associated with abnormal cardiac morphology and were preceded by abnormal Pitx2c expression in the lateral plate mesoderm. In situs inversus embryos there was a mirror image...

... contributed equally to this manuscript 06 03 2000 10 05 2000 © 2000 by Company of Biologists 2000 Situs inversus Neural tube defect Left-right asymmetry Ventral node cilia Targeted mutation Insertional mutation Complementation Tg737 ORPK Polaris Asymmetric...

... by immotile cilia . Science 193 , 317 – 319 . 10.1126/science.1084576 Brown , N. A. , Hoyle , C. I. , McCarthy , A. and Wolpert , L. ( 1989 ). The development of asymmetry: the sidedness of drug-induced limb abnormalities is reversed in situs inversus mice . Development...

.... * Author for correspondence (e-mail: [email protected] ) 06 02 1995 © 1995 by Company of Biologists 1995 axis formation left-right asymmetry cardiac development situs inversus Xenopus The vertebrate body plan develops along three geometric axes: anterior...

... death during mammalian development. * Author for correspondence 20 05 1994 © 1994 by Company of Biologists 1994 insertional mutagenesis limb development apoptosis situs inversus Recently limb development has become an attractive model for studying the molecular basis...

...Nigel A. Brown; Afshan Mccarthy; Lewis Wolpert Mutant iv/iv mice develop as if they have no sense of left and right, so the development of asymmetry is random: half normal, half as a mirror-image of normal, situs inversus . We have made aggregation chimeras of 8-cell stage iv/iv and +/+ embryos...

..., but the control of asymmetry appears to be random, that is 50 % develop normally (situs solitus), 50 % with laterally inverted viscera (situs inversus). We find that the handedness of induced asymmetric limb defects is highly correlated with embryonic visceral situs. Right limb defects are induced in situs...