... declare no competing financial interests. 4 5 2013 12 9 2013 © 2013. Published by The Company of Biologists Ltd 2013 Basic helix-loop-helix Coe Single-minded Hes Neurogenesis Lophotrochozoan Planarians Regeneration Schmidtea mediterranea Stem...

... by establishing differential cell fates in adjacent regions of the neurogenic ectoderm. In this study, we examine the function of the ventral midline and the midline-associated gene single-minded ( Ph-sim ) in the amphipod crustacean Parhyale hawaiensis . Remarkably, we found that Ph-sim and the ventral midline...

...% reduction in the number of cortical CNS cells. A similar thinning of the ventral nerve cord can be observed following mechanical ablation of the midline cells. We have identified a number of specific neuronal and glial cell markers that are reduced in CNS midline-less embryos (in single-minded embryos...

...Margaret Sonnenfeld; Mary Ward; Gerald Nystrom; Jack Mosher; Stephanie Stahl; Stephen Crews ABSTRACT The Drosophila single-minded and trachealess bHLH-PAS genes control transcription and development of the CNS midline cell lineage and tracheal tubules, respectively. We show that Single-minded...

... results also showed that SINGLE-MINDED/dARNT heterodimers, which are essential for breathless expression in midline precursor cells, share DNA targets in common with TRACHEALESS/dARNT, indicating that two different basic helix-loop-helix-PAS protein complexes act through the same target sites in vivo...

... embryos, neuroectodermal genes, such as single-minded and rhomboid , are derepressed while ventral invagination proceeds normally. However, the differentiation of these invaginated cells into mesodermal lineage is disrupted. The results suggest that the establishment of mesodermal cell fate requires...

... of the brain commissure. Mutations in the single-minded gene and in other spitz group genes, which affect the differentiation of CNS midline cells, result in the absence or aberrant projection of longitudinal pathways. The analysis of axon pathway formation presented here reveals remarkable similarities...

... of the mesectoderm. This has been shown for neuralized and Notch , and could also be the case for Delta and for the Enhancer of split gene complex. Neurogenic genes would control at the transcriptional level the repression of proneural genes and the activation of single-minded in the anlage of the mesectoderm...

... 1994 by Company of Biologists 1994 CNS midline Drosophila enhancer neurogenesis single-minded transcription xenobiotic response Development of the nervous system in a bilaterally symmetric organism critically depends on cells that lie on its midline. Midline cells in various...