...Carla V. Argañaraz; Tamara S. Adjimann; Paula P. Perissinotti; Mariano Soiza-Reilly ABSTRACT Serotonin (5-hydroxytryptamine, 5-HT) neurons are implicated in the etiology and therapeutics of anxiety and depression. Critical periods of vulnerability during brain development enable maladaptive...

... for cholecystokinin and secretin production. In all stages and Nkx2.2 mutant conditions, serotonin-producing enterochromaffin cells were the most severely reduced enteroendocrine lineage in the duodenum and colon. We determined that the transcription factor Lmx1a is expressed in enterochromaffin cells and functions...

... Glutamate Dopamine Serotonin Midbrain Hindbrain Mouse Chicken Midbrain dopaminergic (DA) and dorsal raphe serotonergic (5-HT) neurons regulate responses to reward and punishment, associative learning, mood, and coordination of voluntary movements. Function of these monoaminergic pathways...

... (Cdk5) is a master regulator of pyramidal neuron migration. Recently, we have shown that Cdk5 binds to the serotonin 6 receptor (5-HT6R), a G protein-coupled receptor (GPCR). Here, we investigated the role of 5-HT6R in the positioning and migration of pyramidal neurons during mouse corticogenesis. We...

... epidermis, characterized by serotonin synthesis and secretion. It is termed small secretory cell (SSC). SSCs are detectable at early tadpole stages, unlike MCCs and ISCs, which are specified at early neurulation. Subcellularly, serotonin was found in large, apically localized vesicle-like structures, which...

... expression of taste bud markers already characterized in jawed vertebrates. Serotonin (5HT) is expressed in basal Merkel-like taste bud cells in fish ( Zachar and Jonz, 2011 ), amphibia ( Barlow and Northcutt, 1995 ; Delay et al., 1993 ) and mammalian presynaptic cells ( Dvoryanchikov et al., 2007...

...Elisa Reisoli; Stefania De Lucchini; Irma Nardi; Michela Ori Serotonin (5-HT) is a neuromodulator that plays many different roles in adult and embryonic life. Among the 5-HT receptors, 5-HT2B is one of the key mediators of 5-HT functions during development. We used Xenopus laevis as a model system...

..., Lmx1b and Gata2 is markedly downregulated. Nevertheless, serotonergic precursors begin to differentiate in Insm1 mutants, but fail to produce serotonin because of a failure to activate expression of tryptophan hydroxylase 2 (Tph2), the key enzyme of serotonin biosynthesis. We find that both Insm1...

... for the differentiation of serotonin-positive cells in r1( Craven et al., 2004 ). Consistent with this, our results show loss of serotonergic neurons in the conditional Gata2 mutants. In contrast to the Gata2 mutant explant cultures, our results suggest that loss of Gata2 also leads to downregulation of Gata3...

... activity sustained elevated Ca i 2+ . On the right, Ca i 2+ levels were actively repressed through the activities of H + K + ATPase and serotonin-dependent signaling, thus identifying a novel mechanism for the known effects of serotonin on laterality. Vitamin A-deficient quail have a high incidence...

... providing a link between environmental signals and developmental regulation. Induced retardation starts from the trochophore stage and results in up to twofold prolongation of the larval lifespan. Upon stimulation with the signal, the neurones increase synthesis and release of monoamines [serotonin (5-HT...

... connections are forming. Although serotonin is a highly conserved neurotransmitter that is important for many CNS functions, little is known about the process of serotonergic neuron differentiation. We show that in Drosophila ,expression of the serotonin transporter (SerT) is both temporally and physically...

...; the neurons are generated but do not express genes necessary for serotonergic neurotransmission. unc-86 -null mutations affect the expression in NSM of tph-1 , which encodes the serotonin synthetic enzyme tryptophan hydroxylase, and cat-1 , which encodes a vesicular transporter that loads serotonin...

... within the Drosophila CNS. *Author for correspondence (e-mail: [email protected] ) 16 11 2001 © 2002. 2002 Drosophila NB sublineage genes hunchback Central nervous system Serotonin Corazonin The central nervous system (CNS) of all higher organisms consists...

...Stephen A. Stricker; Toni L. Smythe ABSTRACT In the nemertean worms Cerebratulus lacteus and Micrura alaskensis , 5-HT (=5-hydroxytryptamine, or serotonin) causes prophase-arrested oocytes to mature and complete germinal vesicle breakdown (GVBD). To identify the intracellular pathway that mediates...

...Martha J. Lundell; Jay Hirsh ABSTRACT During development of the Drosophila nerve cord, neuroblast 7-3 gives rise to a pair of mitotic sister serotonin neurons in each hemisegment. Here we show that the zinc finger gene eagle , which is expressed in neuroblast 7-3, is essential for specifying...

.... elegans nematode neuron serotonin ces-1 ces-2 ced-3 ced-4 During the development of both vertebrates and invertebrates, many cells are bom that neither divide nor form part of the adult, but instead die ( Saunders, 1966 ; Cowan et al . 1984 ; Truman, 1984 ). Programmed cell...

... of enteric neuronal diversity, we examined the expression of serotonin (5-HT), tyrosine hydroxylase and GABA in vitro . In the mature avian intestine, intrinsic neurones contain 5- HT or GABA but not tyrosine hydroxylase. These markers were demonstrated immunocytochemically, singly or simultaneously. All...

...J. M. Lauder; H. Tamir; T. W. Sadler The possible involvement of the neurotransmitter serotonin (5-HT) in morphogenesis of the craniofacial region in the mouse embryo has been investigated using the method of whole-embryo culture. Day-12 embryos were incubated for 3–4 h in the presence of 5-HT...