...Roman Szabo; Taliya Lantsman; Diane E. Peters; Thomas H. Bugge The membrane-anchored serine proteases prostasin (PRSS8) and matriptase (ST14) initiate a cell surface proteolytic pathway essential for epithelial function. Mice expressing only catalytically inactive prostasin are viable, unlike...

...Chio Oka; Rumi Tsujimoto; Miwa Kajikawa; Kazuko Koshiba-Takeuchi; Junko Ina; Masato Yano; Akiho Tsuchiya; Yoshihumi Ueta; Akinobu Soma; Hidenobu Kanda; Michio Matsumoto; Masashi Kawaichi HtrA1, a member of the mammalian HtrA serine protease family, has a highly conserved protease domain followed...

... gene encodes a serine protease that generates processed Spätzle, which is proposed to act as the Toll ligand. By examining the expression domains of the zygotic genes zen, sog, rho and twist , which are targets of nuclear Dorsal, we show that the slope of the Dorsal gradient is progressively flattened...

... cells, which provide dorsoventral positional information for the embryo. The nudel gene product, a large mosaic protein with a central serine protease domain, has been proposed to function in locally triggering a protease cascade that produces the ventral signal. Here we provide evidence that the serine...

...Sima Misra; Peter Hecht; Robert Maeda; Kathryn V. Anderson ABSTRACT The sequential activities of four members of the trypsin family of extracellular serine proteases are required for the production of the ventrally localized ligand that organizes the dorsal-ventral pattern of the Drosophila embryo...

...Pamela M. Carroll; Stella E. Tsirka; William G. Richards; Michael A. Frohman; Sidney Strickland ABSTRACT Tissue plasminogen activator (t-PA) is a secreted serine protease implicated in multiple aspects of development. In the adult rat brain, transcription of t-PA is an immediate-early response...

...Pamela M. Carroll; William G. Richards; Andrew L. Darrow; James M. Wells; Sidney Strickland ABSTRACT The serine protease tissue-plasminogen activator (t-PA) has previously been shown to be intracellular in mouse secondary oocytes and extracellular in fertilized eggs. Here we demonstrate...

...Rebecca Chasan; Yishi Jin; Kathryn V. Anderson The product of the Drosophila easter gene, a member of the trypsin family of serine proteases, must be more active ventrally than dorsally to promote normal embryonic polarity. The majority of the easter protein in the embryo is present...