...-3200, USA 31 05 2000 20 07 2000 © 2000 by Company of Biologists 2000 Brd family Notch signaling Amphipathic helix Drosophila Sensory organ development Neurogenesis Muscle development The Notch (N) pathway is a conserved signal transduction module...

... signaling. We demonstrate that overexpression of any family member antagonizes the activity of the Notch pathway in multiple cell fate decisions during adult sensory organ development. These results suggest that Bearded family genes encode a novel class of effectors or modulators of Notch signaling...

..., 1300 Morris Park Avenue, Bronx, NY 10461, USA § Author for correspondence (e-mail: [email protected] ) 19 04 1999 05 03 1999 © 1999 by Company of Biologists 1999 Drosophila melanogaster Neurogenesis Sensory organ development shavevn ( sv ) Pax genes...

... address: Exelixis Pharmaceuticals, 260 Littlefield Avenue, South San Francisco, CA 94080, USA ‡ Author for correspondence (e-mail: [email protected] ) 14 September 1998 03 August 1998 © 1998 by Company of Biologists 1998 Neurogenesis Sensory organ development 3...

... to be dependent on transgene insertion in rare, extremely highly expressed regions of the genome. * Author for correspondence (e-mail: [email protected] ) 18 09 1997 © 1997 by Company of Biologists 1997 Drosophila neurogenesis sensory organ development 3′ untranslated region...

... mis-expression effect. Consistent with the specific effects of Brd gain-of-function mutations on adult sensory organ development, and the lack of wing vein or wing blade defects common to many other bristle mutants, Brd is expressed specifically in the proneural clusters of the wing...

... in adult sensory organ development, decreasing or increasing the level of Sup-pressor of Hairless function confers mutant phenotypes that closely resemble those associated with gain and loss of Hairless activity, respectively. These results, along with the intermediate SOP phenotype observed in Suppressor...

... by Company of Biologists 1992 ryanodine and IP3 receptors mesodermal expression sensory organ development tubular muscles antennal expression Fig. 3. Expression of dry mRNA during embryonic development. Figures show the hybridization pattern of a digoxigenin-labelled dry cDNA probe...