... conferred by segment polarity genes and dorsoventral patterning genes. We have studied mechanisms leading to the fate specification of a set of late delaminating neuroblasts, NB 6-4 and NB 7-3, both of which arise from the engrailed ( en ) expression domain, with NB 6-4 delaminating first. In contrast...

... ( Boutros et al., 1998 ). This could also explain why DTak has a stronger effect, as it may be upstream of more than one MAPK module. Fig. 3. Elevated JNK signaling suppresses arm . Cuticle preparations with anterior up. (A) Wild type; (B) arm XP33 / Y . Note defects in segment polarity...

... the whole denticle pattern. Author for correspondence (e-mail: [email protected] ) 24 11 1999 05 10 1999 © 1999 by Company of Biologists 1999 Drosophila Denticle pattern Segment polarity Hedgehog Wingless Egfr Notch The embryonic epidermis of Drosophila...

... with endogenous wild-type Fu we used the fu A allele that produces a segment-polarity lethal embryonic phenotype. Because fu A homozygous mutant embryos can be rescued by maternal wild-type Fu we were able to obtain viable fu A adults that did not express functionally active endogenous Fu. We first...

... 1997 © 1997 by Company of Biologists 1997 optomotor-blind hedgehog pattern formation segment polarity Drosophila The epidermis of each segment in Drosophila is subdivided into anterior and posterior lineage compartments defined by expression of the engrailed ( en...

... 1997 by Company of Biologists 1997 hedgehog engrailed pattern formation segment polarity gradient compartment Drosophila The epidermis of the embryonic segments and imaginal discs of Drosophila is organized into lineage compartments defined by expression of selector genes...

... and that they account for the main difference in shape between abdominal and thoracic denticle belts. * Author for correspondence (e-mail: [email protected] ) 18 06 1997 © 1997 by Company of Biologists 1997 EGFR signalling Wingless segment polarity larval cuticle faint little ball...

... Drosophila neurogenesis segment polarity The wingless ( wg ) gene is the best characterized member of the Wnt family, which contains over fifty genes in organisms ranging from nematodes to humans ( Nusse and Varmus, 1992 ). Wnt genes encode cysteine-rich proteins containing signal sequences...

... patterning by Hh in the dorsal epidermis. * Author for correspondence 22 12 1995 © 1996 by Company of Biologists 1996 Hedgehog Wingless Lines segment polarity Drosophila During development, pattern must be established across fields of cells. This involves...

... phenotypes . Development 118 , 401 – 415 . 10.1242/dev.118.2.401 Capdevila , J. , M. P. Estrada , E. Sánchez-Herrero and I. Guerrero ( 1994 ) The Drosophila segment polarity gene patched interacts with decapentaplegic in wing development . EMBO J . 13 , 71 – 82...

...Armen S. Manoukian; Kenneth B. Yoffe; Elizabeth L. Wilder; Norbert Perrimon ABSTRACT The Drosophila segment polarity gene wingless (wg) is required in the regulation of engrailed (en) expression and the determination of cell fates in neighboring cells. This paracrine wg activity also regulates...

.... 18 wheeler transcripts accumulate in embryos in a pattern reminiscent of segment polarity genes. Mutations in 18w cause death during larval development and early adulthood. Escaping mutant adults often display leg, antenna, and wing deformities, presumably resulting from improper eversion of imaginal...

...Marcel van de Heuvel; John Klingensmith; Norbert Perrimon; Roel Nusse ABSTRACT By a complex and little understood mechanism, segment polarity genes control patterning in each segment of the Drosophila embryo. During this process, cell to cell communication plays a pivotal role and is under direct...

...Naren R. Ramakrishna; Anthony M. C. Brown ABSTRACT The segment polarity gene wingless is the Drosophila ortholog of mouse Wni-1, a proto-oncogene capable of causing transformation of mammary epithelial cells. These two genes presently represent the best studied members of the Wnt gene family...

...Amy Bejsovec; Eric Wieschaus ABSTRACT Each segment of a Drosophila larva shows a precisely organized pattern of cuticular structures, indicating diverse cellular identities in the underlying epidermis. Mutations in the segment polarity genes alter the cuticle pattern secreted by the epidermal cells...

... of transcripts encoded by the pair-rule genes fushi tarazu ( ftz ) and even-skipped ( eve ) and later by stripes encoded by the segment polarity genes engrailed ( en ) and wingless . Here, we show that the runt gene ( run ) is required to generate asymmetries within these parasegmental domains. Using a heat...

.... and Ready , D. F. ( 1991 ). Cell death m normal and Rough eye mutants of Drosophila Development 113 , 825 – 840 10.1242/dev.113.3.825 03 02 1992 © 1992 by Company of Biologists 1992 segment polarity cell lineage homeotic mutations Drosophila gene expression...

... wingless segment polarity Drosophila segmentation pattern formation The larval epidermis of insects secretes a highly patterned array of cuticular structures, revealing an underlying pattern of differences in the epidermal cells within each segment ( Wigglesworth, 1940 ; 1973 ). For example...

..., the stripes of the pairrule gene even-skipped (eve) sharpen and polarize, a process that is essential for the precisely localized expression of segment polarity genes. This sharpening process appears to depend on a threshold response of the eve promoter to the combinatorial action of eve and a second pair...

...Roger G. Phillips; Ian J. H. Roberts; Philip W. Ingham; J. Robert S. Whittle We demonstrate the role of the segment polarity gene patched (ptc) in patterning in the cuticle of the adult fly. Genetic mosaics of a lethal allele of patched show that the contribution of patched varies in a position...