... and for transcription of a core set of midline glial-expressed genes. The Hedgehog morphogen is secreted from ectodermal cells adjacent to the CNS midline and directs a subset of midline glia to become PMG. Two transcription factor genes, runt and engrailed , play important roles in AMG and PMG development. The runt...

..., but the evolutionary origin of the mechanism, the pair-rule system, is unclear. We have examined the expression of the homologues of two Drosophila pair-rule genes, runt and paired (Pax Group III), in segmenting embryos of the two-spotted spider mite ( Tetranychus urticae Koch). Spider mites are chelicerates, a group...

...Joshua S. Kaminker; Rajan Singh; Tim Lebestky; Huajun Yan; Utpal Banerjee The Core Binding Factor is a heterodimeric transcription factor complex in vertebrates that is composed of a DNA binding α-subunit and a non-DNA binding β-subunit. The α-subunit is encoded by members of the Runt Domain family...

...Ling-Hui Li; J. Peter Gergen Brother and Big brother were isolated as Runt-interacting proteins and are homologous to CBF β, which interacts with the mammalian CBF α Runt-domain proteins. In vitro experiments indicate that Brother family proteins regulate the DNA binding activity of Runt-domain...

...Gail V. Flores; Andrea Daga; Hamid R. Kalhor; Utpal Banerjee ABSTRACT In the developing Drosophila eye, individual cell fates are specified when general signaling mechanisms are interpreted in the context of cell-specific transcription factors. Lozenge, a Runt/AML1/CBFA1-like transcription factor...

...Emma-Louise Dormand; Andrea H. Brand ABSTRACT The segmentation gene, runt , is expressed by a subset of the 30 neuroblasts that give rise to each neuromere of the Drosophila embryo. Runt activity in the neuroblasts is necessary for expression of even-skipped in the EL neurons. runt is therefore...

...Chihcheng Tsai; Peter Gergen ABSTRACT The segmentation genes runt and hairy are required for the proper transcriptional regulation of the pair-rule gene fushi tarazu during the blastoderm stage of Drosophila embryogenesis. The expression of different fushi tarazu reporter genes was examined in runt...

...Chihcheng Tsai; J. Peter Gergen ABSTRACT The Drosophila Runt protein is a member of a new family of transcriptional regulators that have important roles in processes extending from pattern formation in insect embryos to leukemogenesis in humans. We used ectopic expression to investigate runt ’s...

... of transcripts encoded by the pair-rule genes fushi tarazu ( ftz ) and even-skipped ( eve ) and later by stripes encoded by the segment polarity genes engrailed ( en ) and wingless . Here, we show that the runt gene ( run ) is required to generate asymmetries within these parasegmental domains. Using a heat...

...J. B. Duffy; M. A. Kania; J. P. Gergen ABSTRACT The Drosophila gene runt was initially identified on the basis of its role during segmentation. Recent molecular and genetic studies have demonstrated that the runt gene encodes a novel nuclear protein whose developmental importance is not exclusive...